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Metabolic Effects of Medium-Chain Fatty Acids in Patients With Medium-Chain Acyl-CoA Dehydrogenase Deficiency and Healthy Individuals

ConditionMedium-chain Acyl-CoA Dehydrogenase Deficiency
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorUniversity of Copenhagen

About this trial

The aim of this project is to investigate the physiological effects of intake of long-chain fatty acids (LCFA) and medium-chain fatty acids (MCFA) in patients with Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) and healthy individuals

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Male or female

Age between 18-80 years old

Diagnosed Medium-chain acyl-CoA dehydrogenase deficiency (MCADD

Male or female

Disqualifiers

Diabetes

Kidney- or liver disease

Use of beta blockers or diuretics

Pregnant, lactating or planning to become pregnant within the study period

Trial design

Design model

Crossover

Treatments tested in this trial

  • Medium-Chain Fatty Acid (MCFA)

    Other intervention

    The participants will consume Medium-Chain Fatty Acid (MCFA) followed by Long-Chain Fatty Acid (LCFA)

  • Long-Chain Fatty Acid (LCFA)

    Other intervention

    The participants will consume Long-Chain Fatty Acid (LCFA) followed by Medium-Chain Fatty Acid (MCFA).

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: Healthy ParticipantsExperimental treatment 2 interventions
Group B: MCADD PatientsExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Ketone Bodies

To measure the effect of Medium-Chain Fatty Acid (MCFA) and Long-Chain Fatty Acid (LCFA) on circulating ketone body concentrations.

Time frame
During both individual test days

Secondary outcomes

1

Resting metabolic rate

To measure the effect of Medium-Chain Fatty Acid (MCFA) and Long-Chain Fatty Acid (LCFA) on resting metabolic rate.

Time frame
During both individual test days
2

Respiratory exchange ratio

To measure the effect of Medium-Chain Fatty Acid (MCFA) and Long-Chain Fatty Acid (LCFA) on respiratory exchange ratio.

Time frame
During both individual test days
3

Vasodilator Function

To measure the effect of Medium-Chain Fatty Acid (MCFA) and Long-Chain Fatty Acid (LCFA) on vasodilator function.

Time frame
During both individual test days
4

Fatty Acid Composition

To measure the effect of Medium-Chain Fatty Acid (MCFA) and Long-Chain Fatty Acid (LCFA) on fatty acid composition.

Time frame
During both individual test days

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Copenhagen

Lead sponsor

Copenhagen Neuromuscular Center

Collaborator

Center of Inherited Metabolic Diseases, Copenhagen University Hospital Rigshospitalet

Collaborator

Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark

Collaborator

Source ClinicalTrials.gov
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