Metabolic Effects of Short-Chain Fatty Acids in Healthy Individuals
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorUniversity of Copenhagen
About this trial
The primary objective of this study is to investigate the acute physiological and metabolic effects of ingesting the short-chain fatty acids (SCFA)s propionate (three carbon atoms long; C3:0) and butyrate (C4:0) in healthy men and women. This aim will be addressed through a block-randomized cross-over study including two visits with acute intake of propionate and butyrate, respectively.
The hypothesis is that plasma ketone body levels will increase during the first three hours after intake of butyrate, but not propionate, in healthy individuals in the overnight fasted state.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Male or female.
Age between 18-40 years old
BMI between 18.5-29
Disqualifiers
Diabetes
Kidney- or liver disease
Pregnant, lactating or planning to become pregnant within the study period
Supplementation with SCFAs
Trial design
Design model
Crossover
Treatments tested in this trial
Propionate followed by Butyrate
Other interventionThe participants will consume Short-chain fatty acid propionate (SCFA-PRO) followed by Short-Chain Fatty Acid Butyrate (SCFA-BUT).
Butyrate followed by Propionate
Other intervention• The participants will consume Short-chain fatty acid Butyrate (SCFA-BUT) followed by Short-Chain Fatty Acid Propionate (SCFA-PRO).
Propionate followed by Butyrate
Other intervention• The participants will consume Short-Chain Fatty Acid propionate (SCFA-PRO) followed by Short-Chain Fatty Acid Butyrate (SCFA-BUT).
Butyrate followed by Propionate
Other interventionThe participants will consume Short-Chain Fatty Acid Butyrate (SCFA-BUT) followed by Short-Chain Fatty Acid Propionate (SCFA-PRO).
Treatment groups
10 Participants
are divided into 2 treatment groupsGroup A: FemaleExperimental treatment 2 interventions
Group B: MaleExperimental treatment 2 interventions
Trial outcomes
Primary outcomes
1
Ketone Bodies
To measure the effect of Short-Chain Fatty Acid Butyrate (SCFA-BUT) and Short-Chain Fatty Acid Propionate (SCFA-PRO) on circulating ketone body concentrations.
Time frame
On day 1 (test day 1) and day 2 (test day 2) at baseline (-30 min and 0 min) and post intake (10 min, 15 min, 22.5 min, 30 min, 45 min, 60 min, 90 min, 120 min, and 180 min).Secondary outcomes
1
Glucose
To measure the effect of Short-Chain Fatty Acid Butyrate (SCFA-BUT) and Short-Chain Fatty Acid Propionate (SCFA-PRO) on circulating glucose.
Time frame
On day 1 (test day 1) and day 2 (test day 2) at baseline (-30 min and 0 min) and post intake (10 min, 15 min, 22.5 min, 30 min, 45 min, 60 min, 90 min, 120 min, and 180 min).2
Fatty acids
To measure the effect of Short-Chain Fatty Acid Butyrate (SCFA-BUT) and Short-Chain Fatty Acid Propionate (SCFA-PRO) on circulating Short-Chain Fatty Acids.
Time frame
On day 1 (test day 1) and day 2 (test day 2) at baseline (-30 min and 0 min) and post intake (10 min, 15 min, 22.5 min, 30 min, 45 min, 60 min, 90 min, 120 min, and 180 min).3
Flow mediated dilation measurement
To measure the vasodilatory effects of the short-chain fatty acids butyrate (SCFA-BUT) and propionate (SCFA-PRO) during flow-mediated dilation measurement.
Time frame
On day 1 (test day 1) and day 2 (test day 2) at baseline (min -15) and post intake (min 90).4
Resting metabolic rate
To measure the effect of Short-Chain Fatty Acid Butyrate (SCFA-BUT) and Short-Chain Fatty Acid Propionate (SCFA-PRO) on resting metabolic rate.
Time frame
On day 1 (test day 1) and day 2 (test day 2) at baseline (min -15) and post intake (30 min, 60 min, 120 min)Sponsors and contacts
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Source ClinicalTrials.gov