Metabolic Exercise Testing
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age5+
SponsorUniversity Hospital, Brest
About this trial
Exertional symptoms are the hallmarks of metabolic myopathies, supporting the concept of using functional tests when this diagnosis is suspected. Exercise increases the concentration of muscle metabolites in the venous blood supply (e.g. lactate, pyruvate, and ammonia) especially during recovery. The purpose of this study is to compare the results of exercise testing with to the data from muscle biopsy or genetic analysis.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Referred to the Physiology Department of Brest Hospital for a metabolic exercise test
Ability to provide informed consent
Disqualifiers
Contraindication(s) to perform cardiopulmonary exercise testing (ATS/ACCP statement on cardiopulmonary exercise testing, Am J respi Care Med 167: 211-77, 2003)
Pregnancy or unknown pregnancy status.
Trial population
Subjects referred to perform a metabolic exercise testing.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
functional test
Devicesubjects perform a metabolic exercise testing
matching genotype with phenotype
Genetic
Treatment groups
1,000 Participants
are divided into 1 treatment groupGroup A: metabolic exercise testing2 interventions
Trial outcomes
Primary outcomes
1
Whole-body dynamic exercise
The relation between Cardiopulmonary exercise test variables and the results of muscle biopsy or genetic analysis will be evaluated.
Time frame
Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed2
Grip-test
The relation between Grip-test variables and the results of muscle biopsy or genetic analysis will be evaluated.
Time frame
Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed3
Blood tests
The results of blood analysis from samples performed before, during, and after exercise will be compared to the results of muscle biopsy or genetic analysis.
Time frame
Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performedSponsors and contacts
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Source ClinicalTrials.gov