POWER Health is a randomized clinical trial with a two-arm parallel design whose objectives are 1) to study metabolic flexibility and autonomic function (both capacities that describe cardiovascular health) in a sample of postmenopausal oncological women vs postmenopausal untreated controls (CT); and 2) to analyze the impact of two different 8-week physical exercise supervised interventions: HIIT training vs strength training focused on muscle power, on both cardiovascular capacities in these populations.
Patients diagnosed of relapse free-cancer (RFC) or patients not diagnosed of any cancer at least the last 15 years (CG)
Aged between 35 and 75 years
Diagnostic of breast cancer (i.e., including ductal carcinoma, invasive carcinoma, triple negative; RFC) or physiological menopause (CG)
Not participating in a nutritional/dietary intervention
Medical contraindication for being engaged in an exercise.
Additional surgery planned within the intervention
Consuming usually betablocker or any drugs alterning nervous system functioning
History of another primary invasive cancer (RFC) or suffer a serious chronic illness (CG)
Parallel
HIIT program (8 weeks)
BehavioralMetabolic Power Training: A High Intensity Interval Training (HIIT) intervention, 3 times per week (30 min session) during 8 weeks with professional supervision and intensities adapted and modified during the intervention period.
MPI program (8 weeks)
BehavioralMuscle Power Intervention (MPI), 2 times per week (45 min session) during 8 weeks with professional supervision and intensities adapted and modified during the intervention period.
Fat oxidation during incremental test
Fat oxidation rates calculated from VO2 and VCO2 values collected by indirect calorimetry (COSMED K5 portable metabolic analyzer, Rome, Italy) and after applying Frayn's stoichiometric formulae, during an incremental test from 0.45 W/kg with 0.15W/kg each 4-min step
Detrended Fluctuation Analysis
Non-linear mathematical variable that allows collecting physiological information and vagal activity of the organism, analysed in 2-minute intervals by Kubios Scientific software (Kuopio, Finland), during the incremental test
Weight
Weight measured with a scale (kg)
Height
Height measured with a stadiometer (cm)
Calf, waist and hip circumferences.
Calf, waist and hip circumferences will be assessed with an anthropometric tape measure (cm)
Lean mass
Body composition assessment will be obtained by bioimpedance (Tanita DC-430 MA S; Tokyo, Japan; kg)
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University of Valencia
Lead sponsor
Generalitat Valenciana
Collaborator
