About this trial
The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice but are not consumed frequently enough in older adults. Studies have shown that regular nut consumption is associated with lower adiposity and reduced weight gain, and several dietary pattern studies indicate that nuts and legumes are associated with better bone health. In addition, our preliminary translational data indicates that a higher monounsaturated fatty acid (MUFA) intake is associated with improved bone mineral density (BMD) and quality. Given these findings, the proposed study aims to examine the impact of consuming peanut products on bone health, metabolic health (e.g., serum glucose, insulin, lipids and inflammation), markers of brain and sleep health, and physical function in overweight and obese older adults before and after a six-month weight loss intervention using a randomized controlled design. The results of this study have the potential to provide valuable insights into the role of peanuts as a sources of fatty acids in promoting health and preventing disease in at-risk adults.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Men and postmenopausal women (>2 years since last menses), ages 50-75 years
Body mass index (25-42 kg/m2) or evidence of pre-clinical obesity.
Agree to be randomly assigned to consume a daily peanut snack or nut-free snack for 24 weeks
Must attend on-site visits (about 10) in New Brunswick, NJ, USA (transportation/reimbursement for travel not included)
Disqualifiers
Peanut allergies or intolerances
Participants with >5% weight loss in the past 6 months or extreme dietary/physical activity habits
An inability to follow the experimental intervention or to perform the required specimen collections.
Individuals with significant psychiatric or food disorders.
Trial design
Parallel
Treatments tested in this trial
Peanut Snack Experimental
Dietary supplementSubjects will receive a daily peanut snack and nutrition education-behavior modification instructions for weight loss
Nut-free Snack
Dietary supplementSubjects will receive a daily peanut snack and nutrition education-behavior modification instructions for weight loss
Treatment groups
Trial outcomes
Primary outcomes
Bone Mineral Density (BMD - hip)
dual energy x-ray absorptiometry; g/cm2
Secondary outcomes
Soft tissue (lean and fat mass)
dual energy x-ray absorptiometry (kg)
Serum bone turnover
Serum levels (ng/mL) of carboxyterminal crosslinking telopeptide of type I collagen (CTX), procollagen type-I aminoterminal propeptide (PINP), and osteocalcin
Areal BMD
Dual energy x-ray absorptiometry: lumbar spine, femoral neck, radius, total body, g/cm2
Weight loss
Body weight in kg
Other outcomes
Short Physical Performance Battery (SPPB)
Modified SPPB includes chair stand, balance test on1 leg and walk test (0-12; higher score is better)
Arm Curl
Dumbbell weight (More arm curls are better. Score interpretation is age and sex dependent)
Hand Grip
Dynamometer (kilograms, higher is better)
Circumferences
tape measure (waist and hip)
Sponsors and contacts
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