Inflammatory bowel diseases, Crohn's disease and haemorrhagic rectocolitis, are pathologies that progress in flare-ups, impacting on patients' quality of life and functional or even vital prognosis. These inflammatory diseases require the use of immunosuppressive and immunomodulatory treatments, the side-effects of which can be significant, and the limited number of which sometimes puts patients and practitioners in a therapeutic impasse from which surgery is the only way out. It is therefore important to be able to develop new therapeutic approaches, ideally better tolerated, that can control inflammation during relapses. Monocytes are one of the main players in the inflammatory reaction. In the laboratory, we have developed a strategy for the metabolic reprogramming of these cells based on the use of oxygen microbubbles to modulate the inflammatory response of monocytes.
Men and women over 18
Managed at the CHUGA for a severe IBD flare-up requiring hospitalisation or endoscopy for flare-up
Patient not objecting to the REPRO-MICI study
Patients protected by law (pregnant or breast-feeding women, minors, patients under guardianship or trusteeship, persons deprived of their liberty or hospitalised under duress).
Patients with positive HIV, HBV or HCV serology.
Patients with a positive ELISPOT with no history of treatment for latent tuberculosis.
Patients with IBD in severe relapse requiring hospitalisation for immunosuppressive therapy or endoscopy for relapse.
Case-only
Prospective
Blood test 4 EDTA tubes
Biological/VaccineBlood test 4 EDTA tubes for biological check-up
Comparaison of reduction of concentration of inflammatory cytokines and chemokines in cells treated by oxygen microbubbles vs cells not treated
Validation of inhibition of the production of inflammatory cytokines and chemokines by the monocytes treated by oxygen microbubbles
Comparaison of tissue factor expression at the membrane of monocytes treated by microbubbles vs monocytes not treated
Inhibition of tissue factor expression at the membrane of treated monocytes
Comparaison of glucose metabolism rate in monocytes treated bu microbubbles vs not treated cells
Modulation of glucose metabolism in treated monocytes
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University Hospital, Grenoble
Lead sponsor
Institute for Advanced Biosciences (IAB), Grenoble
Collaborator
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