Metabolic Responses to Bariatric Surgery
ConditionMorbid Obesity
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-55
SponsorUniversity of California, Davis
About this trial
Research the genetic and biomechanical markers of human adipose tissue on patients with morbid obesity. Additional tissue/fluid collection is also gathered during the time of surgery.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Meet NIH Criteria for Bariatric Surgery
Between the Age of 18-55
Dyslipidemia controlled with medication
Impaired glucose metabolism or type 2 diabetes
Disqualifiers
Uncontrolled Metabolic syndrome (uncontrolled diabetes, htn, dyslipidemia), one or all conditions.
Trial population
Patients who present for bariatric surgery to treat morbid obesity.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Surgery
Other interventionPatients wishing to participate in the research will complete all necessary pre-operative work-up labs, testing \& counseling, complete and sign the informed consent. During weight loss surgery a small amount of subcutaneous and omental fat will be collected for analysis, with subsequent blood collection post surgery for analysis.
Treatment groups
500 Participants
are divided into 2 treatment groupsGroup A: Weight Loss Surgery - Healthy1 intervention
Group B: Weight Loss Surgery - Metabolic Syndrome1 intervention
Trial outcomes
Primary outcomes
1
Tensile Strength of White Adipose Tissue
During the research tissue samples were compared between healthy obese patients (no diabetes, controlled HTN, no dyslipidemia) with tissue samples collected on non-healthy obese patients (type II diabetes) and using fat collected from mice as a control.
Time frame
July 2012Sponsors and contacts
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Source ClinicalTrials.gov