Metabolomics-Driven Insights Into Ultra-Processed Foods
ConditionDiet, Food and Nutrition
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-65
SponsorBrigham and Women's Hospital
About this trial
The goal of this dietary intervention study in generally healthy adults is to develop new ways to use blood samples to measure the common types of highly processed foods and beverages that people eat on a regular basis. The main aims to answer are:
What small molecules are elevated in blood after eating different types of highly processed foods and beverages consistently for 1 week?
Researchers will compare 3 different test diets with 1 control diet that does not have any highly processed foods in the same individuals to see which circulating blood markers change.
Participants will:
* Complete 3 diet phases, each 2 weeks long * Receive a meal plan and study foods and beverages to follow for each 2-week phase * Come to the clinic every week for blood draws, urine samples, and stool collection kits
Eligibility criteria
Qualifiers
Adults, ages 20 to 65 years.
BMI 18.5 to 39.9 kg/m2.
No known food allergies, intolerances, or sensitivities (e.g., gluten, dairy, monosodium-glutamate).
Not following a restrictive diet for health, religious, or other reasons (e.g., vegetarian, vegan).
Disqualifiers
BMI <18.5 or >39.9 kg/m2.
Pregnant, lactating, or planning on becoming pregnant in the next 6 months.
History of bariatric surgery.
Currently taking medications impacting appetite or body weight.
Trial design
Treatments tested in this trial
- UPF Test Diet A: Starchy, refined grains
- UPF Test Diet B: Meat, fish, and bread products
- UPF Diet C: Dairy products, including cheese and cream
Treatment groups
40 Participants
are divided into 6 treatment groups6
Treatment groupsSee each treatment group below.
Sponsors and collaborators
Brigham and Women's Hospital
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Broad Institute of MIT and Harvard
Collaborator
Source ClinicalTrials.gov