Metabolomics in the Diagnosis and Treatment of Asthma in Children
ConditionAsthma
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age12-17
SponsorI.M. Sechenov First Moscow State Medical University
About this trial
The goal of this observational study is to learn about the metabolomic profile of blood and urine in children 12-17 years with asthma. The main question it aims to answer is:
• Are there metabolites in the blood and urine that are specific for asthma exacerbation? Participants already receive standard therapy as part of their regular medical care for asthma.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age from 12 to 17 years old
Confirmed diagnosis of asthma
Informed voluntary consent to participate in the study
Disqualifiers
age under 12 years
no established diagnosis of asthma
concomitant severe somatic, metabolic, and endocrine diseases
patient's withdrawal of informed consent
Trial population
The study will include children hospitalized in the pulmonology department of the Sechenov Center for Maternity and Childhood Care at Sechenov University.
Trial design
Design model
Case-only
Time perspective
Prospective
Treatments tested in this trial
Standart medical treatment
DrugNo intervention, patients will recieve standard medical treatment
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
inflammation biomarkers
Identification of metabolomic changes (inflammation biomarkers) in the blood (aminoacids) and urine (organic acids) of patients with mild, moderate, and severe bronchial asthma associated with asthma exacerbation.
Time frame
baseline and 10 daysSecondary outcomes
1
metabolomic changes
Changes in the metabolomic profile of blood and urine depending on the severity of asthma and the therapy being administered: compare the urine metabolomic profile for organic acids and aminoacids in blood in children with mild and modereate/severe asthma. Assess the dynamics of blood and urine metabolomic profiles in children with severe asthma before and after therapy with biologic agents.Identify the relationship between the blood and urine metabolomic profile in children with asthma and respiratory function parameters.
Time frame
baseline and 10 daysSponsors and contacts
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Source ClinicalTrials.gov