The primary goal of this randomized controlled trial is to compare the effectiveness of two transdiagnostic psychological treatments, Metacognitive Therapy (MCT) and the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP), for patients with complex anxiety.
Age 18 years or above
Ability to read and speak Swedish
A principal diagnosis of post-traumatic stress disorder, generalized anxiety disorder, social anxiety disorder, or panic disorder
At least one additional comorbid diagnosis (one of the above diagnoses, or obsessive-compulsive disorder, or major depressive disorder)
Current diagnosis of psychosis, bipolar disorder or moderate to severe substance use disorder
Medium to high suicide risk
Psychiatric, somatic or social problems that require primary intervention other than the treatments offered in the study
Concurrent psychological treatment
Parallel
Metacognitive therapy (MCT)
BehavioralMCT is delivered in weekly face-to-face sessions
Unified protocol (UP)
BehavioralUP is delivered in weekly face-to-face sessions
Clinical Severity Rating (CSR): change over time
Diagnoses are assigned a dimensional clinical severity rating on a scale from 0 (no symptoms) to 8 (extremely severe symptoms), with a rating of 4 or higher representing the clinical threshold for diagnostic criteria. Observer-assessed.
Overall Anxiety Severity and Impairment Scale (OASIS): change over time
Self-reported anxiety
Overall Depression Severity and Impairment Scale (ODSIS): change over time
Self-reported depression
Generalized Anxiety Disorder-7 (GAD-7): change over time
Self-reported anxiety
Patient Health Questionnaire-9 (PHQ-9): change over time
Self-reported depression
Click on the lead sponsor to view all of their trials.
Karolinska Institutet
Lead sponsor
Region Stockholm
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
