Health Trials

Metaphylaxis of Infected Kidney Stones After Percutaneous Nephrolithotripsy

ConditionsKidney CalculiNephrolithiasisUrinary Tract Infections
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorWest Kazakhstan Marat Ospanov Medical University

About this trial

Kidney stone recurrence, particularly infection-related stones, remains a significant clinical problem after percutaneous nephrolithotripsy (PCNL). Bacterial colonization and persistent infection are recognized contributors to stone recurrence.

This study evaluates the effectiveness of intrarenal dioxidine instillation as a metaphylactic measure to reduce recurrence of infection-related kidney stones following PCNL. Patients undergoing PCNL will receive standard treatment, with or without adjunctive intrarenal dioxidine administration. The study aims to assess whether this approach reduces stone recurrence and infection-related complications.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Dioxidine

    Drug

    Intrarenal instillation of dioxidine solution after PCNL to reduce bacterial colonization and prevent recurrence of infection-related stones.

  • Percutaneous Nephrolithotripsy (PCNL)

    Procedure/Surgery

    Standard percutaneous nephrolithotripsy procedure for removal of kidney stones.

Treatment groups

95 Participants
are divided into 2 treatment groups
Group A: Intrarenal Dioxidine GroupExperimental treatment 2 interventions
Group B: Standard Treatment GroupActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Recurrence of infection-related kidney stones

Proportion of patients with recurrent infection-related kidney stones within 12 months after percutaneous nephrolithotripsy, assessed by imaging studies (ultrasound or CT) and clinical evaluation.

Time frame
12 months post-PCNL

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

West Kazakhstan Marat Ospanov Medical University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: