Methacholine Challenge Test (MCT) in Healthy Adults
ConditionHyperreactive Airway Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorAllergi- og Lungeklinikken, Elsinore
About this trial
Knowledge of Methacholine Challenge Test (MCT) and impedance Oscillometry (IOS) is limited. Only three studies have included adult patients, and none of these with healthy controls. The three studies have combined IOS and spirometry in the same test, although it is not recommended to perform IOS after a test that requires deep breathing, e.g. FEV1 measurement. Deep breathing is considered to affect the impedance via reduced tone in the smooth muscle.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Forced expiratory volume in the 1. second (FEV1) >80%
FEV1/FVC-ratio >0,7
FeNO <25 pbb
Oxygen saturation (SatO2) >95%
Disqualifiers
Any lung disease
Lung symptoms
Medicine for lung disease
Tobacco smoking
Trial population
Healthy adults
Trial design
Design model
Case-only
Time perspective
Prospective
Treatments tested in this trial
Methacholine Challenge Test
Diagnostic testMCT with IOS alone versus MCT IOS and FEV1 combined
Treatment groups
25 Participants
are divided into 1 treatment groupGroup A: Healthy controls1 intervention
Trial outcomes
Primary outcomes
1
Oscillometry; R5
Resistance at 5 Hz; kPa/L/s with FEV1 measurement
Time frame
baseline (carried out with FEV1 measurement)2
Oscillometry; R5
Resistance at 5 Hz; kPa/L/s change from baseline
Time frame
1-10 days from baseline and carried out without FEV1 measurement3
Oscillometry; R20
Resistance at 20 Hz; kPa/l/s with FEV1 measurement
Time frame
baseline (carried out without FEV1 measurement)4
Oscillometry; R20
Resistance at 20 Hz; kPa/L/s change from baseline
Time frame
1-10 days from baseline and carried out without FEV1 measurementSponsors and contacts
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Source ClinicalTrials.gov