Methodological Study of Exercise and Hypoxic Conditions in Healthy Subjects
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorUniversity Hospital, Grenoble
About this trial
The aim of this protocol is to assess physiological responses during various physical exercise protocols (whole-body exercise such as cycling or treadmill running, or localised exercise such as knee extension) and during inhalation of a gas mixtures with various oxygen contents (similar to exposure at high altitude).
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy male or female volunteers
Aged 18-55
Body Mass Index <30 kg/m²
Participants covered by a social security scheme
Disqualifiers
Cardiorespiratory, metabolic and neurological disorders, or other conditions assessed during the inclusion consultation that may affect physiological responses to exercise or hypoxia
Pharmacological treatment taken during the study, other than oral or implantable contraceptive medication for female volunteers of childbearing age
Trial design
Design model
Single group
Treatments tested in this trial
Exercise and hypoxia
Combination productSubjects will perform an exercise test while inhaling a hypoxic gas mixture
Treatment groups
305 Participants
are divided into 1 treatment groupGroup A: Exercise and hypoxiaExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Muscle oxygenation
Measured by NIRS in % saturation
Time frame
During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise testSecondary outcomes
1
Gas exchange
Oxygen consumption and cardon dioxide production measured at the mouth, measured in ml/min
Time frame
During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test2
Heart rate
Measured by ECG in bpm
Time frame
During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test3
Limb blood flow
Measured by Doppler ultrasound in ml/min
Time frame
During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise testSponsors and contacts
Click on the lead sponsor to view all of their trials.
University Hospital, Grenoble
Lead sponsor
University Grenoble Alps
Collaborator
Source ClinicalTrials.gov
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