The goal of this observational study is to learn about the microexpressions in patients with prolonged disorders of consciousness. The main questions it aims to answer are:
* Inducing micro-expression changes in patients with prolonged disorders of consciousness through various emotional stimuli, and further to achieve precise classification of their levels of consciousness. * Detecting micro-expressions in patients with prolonged disorders of consciousness to assist clinical diagnosis of levels of consciousness, e.g., complement the disgnosis of clinical scales such as CRS-r scale. * By monitoring micro-expression changes in patients with prolonged disorders of consciousness, researchers can explore their residual brain function, thereby advancing research into relevant neural mechanisms.
Participants will be subjected to consciousness assessment by CRS-r scale, and their micro-expression changes in response to various emotional stimuli will be captured, along with the collection of EEG and MRI data. Follow-up evaluations will be conducted using the CRS-R scale and GOS scale, with a follow-up period of 6 months.
Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS;
Aged between 18 and 80 years;
Stable vital signs;
Voluntary participation of family members with signed informed consent;
Locked-in syndrome;
Contraindications for EEG examination;
Contraindications for MRI scanning, such as the presence of internal metallic implants;
Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.
Patients are recruited from both general hospitals and rehabilitation hospitals.
Cohort
Cross-sectional
Facial expression; Electroencephalogram; MRI
Diagnostic testRecording facial expressions of participants, EEG recordings, and MRI scans.
GOSE score
GOS-E is an extended version of the Glasgow Outcome Scale (GOS), which was developed to provide a more detailed assessment of patient functionality and quality of life after experiencing such an injury. It has eight categories: Dead, Vegetative State, Lower Severe Disability, Upper Severe Disability, Lower Moderate Disability, Upper Moderate Disability, Lower Good Recovery, and Upper Good Recovery
CRS-r score
CRS-R a standardized neurobehavioral assessment measure designed for use in patients with disorders of consciousness. The scale is intended to be used to establish diagnosis, monitor behavioral recovery, predict outcome, and assess treatment effectiveness. The CRS-R consists of 6 subscales designed to assess auditory function, receptive and expressive language, visuoperception, communication ability, motor functions, and arousal level.
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First Affiliated Hospital of Zhejiang University
Lead sponsor
Hangzhou Mingzhou Brain Rehabilitation Hospital
Collaborator
Zhejiang Provincial People's Hospital
Collaborator
Zhejiang Provincial Armed Police Corps Hospital
Collaborator
