This study was a prospective multicenter cohort of severe pneumonia. And by collecting clinical samples to clarify the correlation between lung microbiome, intestinal microbiome, host susceptibility, and prognosis of severe pneumonia patients.
None
Expected length of stay in ICU is less than 1 day
Pregnant
Overall, the investigators will include all severe pneumonia patients transferred to the ICU, including community acquired pneumonia, hospital acquired pneumonia, and ventilator-associated pneumonia.
Cohort
Prospective
Metagenomics
Diagnostic testClinical metagenomics is used to evaluate pathogens
The correlation between lung microbiome and disease prognosis
1\. Identification of microbial gene profiles; 2. Analysis of host health dynamics and trends; 3. Identification of host gene mutations; 4. Preliminary model construction; 5. Model optimization and evaluation.
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