About this trial
Recently, few studies have attempted to test the regenerative effects of human insulin application by microneedling on atrophic scars versus other topical preparations. However, the scars were limited etiologically to acne scars. In addition, a lack of inclusion of a control group instead of comparing topical preparations with insulin was also a limitation to these studies. A control group consisting of microneedling alone would have served as a better comparison in order to determine whether the effects of microneedling are augmented by topical protein-rich preparations.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients aged 12 to 60 years
Atrophic scars (traumatic or surgical)
Completely healed scars
Disqualifiers
Patients with a tendency or history of hypertrophic or keloidal scars
Patients who received treatment for their scar in the past 3 months
Diabetic patients or those with a history of Dysglycemia
Pregnant, or lactating females
Trial design
Parallel
Treatments tested in this trial
Microneedling with topical application of regular insulin
Other interventionMicroneeling preformed onto the scar In one group insulin will be applied while saline will be used in the second group
Microneedling with topical application of saline
Other interventionMicroneeling preformed onto the scar In one group insulin will be applied while saline will be used in the second group
Treatment groups
Trial outcomes
Primary outcomes
Change in Scar
According the different scar assessment scores (e.g.POSAS score - The Patient and Observer Scar Assessment Scale score, range from 6 to 60, the higher the score the worse the scar, lowering in the score denotes improvement )
Sponsors and contacts
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