Migraine Attack Treatment Response Molecular and Clinical BiOmarkers (MAMBO) Phase I

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-45
SponsorHospital Universitari Vall d'Hebron Research Institute

About this trial

The goal of this observational study is to identify differential traits in spontaneous migraine attacks that can help us predict the response to treatment with sumatriptan.

Participants will be asked to register the headache characteristics before and after taking sumatriptan and whether the treatment was effective or not during four migraine attacks.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Migraine with or without aura diagnosis according to ICHD-3 criteria

<8 migraine days per month

Be able to read, write and understand instructions.

Have internet access and mail address

Disqualifiers

Active preventive treatment for migraine

Active medication with an effect over the central nervous system

Serious physical or psychiatric condition

Cardiovascular or hepatic disease

Trial population

Otherwise healthy episodic migraine patients.

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

  • Sumatriptan

    Drug

    Register the response to treatment and headache characteristics.

Treatment groups

108 Participants
are divided into 1 treatment group
Group A: episodic migraine1 intervention

Trial outcomes

Primary outcomes

1

Response to sumatriptan

Relief of pain from moderate-severe to mild or absent at 2 hours and 24 hours in 3 out of 4 migraine attacks. The response will be evaluated via questionnaire.

Time frame
24 hours

Secondary outcomes

1

Migraine characteristics

Patients will complete a questionnaire describing the characteristics of migraine attacks in the beginning of the attack, and at timepoints 2 and 24 hours after taking sumatriptan.

Time frame
24 hours

Other outcomes

Sponsors and contacts

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