Mild and Moderate Aortic Regurgitation: Risk Factors for Progress and Outcome
ConditionAortic Regurgitation
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-100
SponsorUppsala University
About this trial
This observational study aims to evaluate risk factors of progress and adverse outcome of aortic regurgitation
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients investigated with echocardiography between January 2003 and March 2025
Age ≥18 years
At least minimal aortic regurgitation
At least one additional echocardiography after the index investigation
Disqualifiers
Age <18 years
Trial population
Adult patients with aortic regurgitation
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
35,000 Participants
are grouped into 1 trial groupGroup A: Patients with aortic regurgitation
Trial outcomes
Primary outcomes
1
Progress of aortic regurgitation
Progress of aortic regurgitation from mild to moderate or severe, or moderate to severe. Progress is defined according to current European Society for Cardiology guidelines using a comprehensive echocardiographic assessment
Time frame
Depending on when the patients was evaluated first, up to approximately 20 years of follow-upSecondary outcomes
1
Surgical treatment of aortic regurgitation or aortic aneurysm
Surgical treatment of aortic regurgitation or aortic aneurysm
Time frame
Depending on when the patients was evaluated first, up to approximately 20 years of follow-up2
Hospitalization for heart failure
Hospitalization for heart failure during follow-up
Time frame
Depending on when the patients was evaluated first, up to approximately 20 years of follow-up3
Hospitalization for stroke or myocardial infarction
Composite endpoint
Time frame
Depending on when the patients was evaluated first, up to approximately 20 years of follow-up4
All-cause mortality
All-cause mortality during follow-up
Time frame
Depending on when the patients was evaluated first, up to approximately 20 years of follow-upSponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: