Mindfulness to Enhance Cognitive Health in Latino Older Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorWashington University School of Medicine
About this trial
The primary objective of the proposed research is to investigate the promise and underlying mechanisms of mindfulness training as a preventative lifestyle intervention to enhance cognitive health in Latino older adults, thereby mitigating risk of Alzheimer's Disease (AD) in a population that may be particularly vulnerable.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Hispanic/Latino
Age 65 and older
Male, female, or non-binary
Community living
Disqualifiers
Clinically unstable psychiatric disorder that requires immediate treatment (e.g., ECT)
Medical conditions suggesting significantly shortened lifespan (e.g., metastatic cancer) or prohibiting safe participation in the interventions/assessments (e.g., Parkinson's disease, musculoskeletal conditions)
Sensory impairment (hearing, vision) preventing participation
Current alcohol or substance abuse
Trial design
Design model
Parallel
Treatments tested in this trial
mindfulness
BehavioralMBSR: Mindfulness Program A novel and culturally-adapted version of the well-validated mindfulness-based stress reduction (MBSR) course will be used for the intervention. The adapted program curriculum embeds core MBSR principles and practices within a culturally responsive didactic framework developed directly from community focus-group feedback. The course will be delivered via a group meeting across 8 weeks, with weekly classes held at a local community center. All classes will be held in hybrid format, with most participants attending in person, but with a live-stream option offered via Zoom.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
EEG brain markers of cognitive functioning
EEG indices of cognitive performances evoked by task stimuli and participant responses. ERP components of attention and cognitive control during task performance, focused on target-related P3 amplitude.
Time frame
Time-frame: 2 time-points - baseline/pre-intervention, and immediately after the intervention2
EEG brain markers of cognitive functioning
EEG indices of cognitive performances evoked by task stimuli and participant responses. ERP components of attention and cognitive control during task performance, focused on cue-related Contingent Negative Variation (CNV).
Time frame
Time-frame: 2 time-points - baseline/pre-intervention, and immediately after the intervention3
AXCPT behavioral performance (reaction time)
Behavioral performance indices during AXCPT task: AX-CPT - reaction time in milliseconds
Time frame
Assessed at 2 timepoints: baseline/pre-intervention immediately post-intervention4
AXCPT behavioral performance score (accuracy)
Behavioral performance indices during AXCPT task: AX-CPT - % accuracy AX-CPT --% accuracy
Time frame
Assessed at 2 timepoints: baseline/pre-intervention immediately post-interventionSecondary outcomes
1
EEG metrics of mindfulness practice quality
EEG spectral power (alpha, theta bands) evoked during guided mindfulness state induction
Time frame
Assessed at 2 timepoints: baseline/pre-intervention immediately post-interventionSponsors and contacts
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Source ClinicalTrials.gov