Mineral-Infused Clothing for Recovery From Muscle Soreness and Muscle Damage After Exercise
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorStudySetGo
About this trial
The goal of this clinical trial is to learn whether wearing mineral-infused clothing helps muscles recover after a hard bout of unaccustomed exercise in healthy adults aged 18 to 45 who have not done lower-body resistance or jump training in the last 6 months.
The main question it aims to answer is: does wearing the mineral-infused garment lead to greater recovery of leg muscle strength (maximal voluntary isometric contraction of the knee extensors) 72 hours after exercise, compared with wearing an identical garment without the mineral infusion?
Researchers will also compare the two garments for recovery of jump performance, muscle soreness and blood creatine kinase (a marker of muscle damage), and will describe garment comfort and tolerability.
Participants will:
* Complete electronic consent, an online screening questionnaire and a video screening call * Attend the study site on four consecutive days * On Day 1, complete baseline tests, then perform 100 drop jumps (5 sets of 20) to cause muscle soreness * Wear their allocated garment for at least 16 hours a day (day and overnight) for the following 72 hours and keep a daily wear log * Have strength, jump and soreness tests and a finger-prick blood sample at each visit (24, 48 and 72 hours after exercise)
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults aged 18 to 45 years inclusive
Body mass index between 18.5 and 29.9 kg/m2 inclusive
No participation in structured lower-limb resistance training or plyometric (jump) training within the previous 6 months (structured training: a planned programme of exercise against external load or bodyweight loading targeting the lower limbs, performed at least once per week for 4 or more consecutive weeks)
No history of injury that may impair the ability to perform maximal exercise
Disqualifiers
Current use of non-steroidal anti-inflammatory drugs, corticosteroids or other anti-inflammatory medication
Current use of statins
Use of dietary supplements with known anti-inflammatory or antioxidant activity
Diagnosed muscle, neuromuscular or connective tissue disorders
Trial design
Design model
Parallel
Treatments tested in this trial
Mineral-infused garment
Other interventionCommercially available lower-limb garments (socks and leggings) with the manufacturer's proprietary mineral formulation incorporated into the textile by a post-manufacturing infusion process. Three new, unworn sets are issued per participant (one per recovery day). Worn during the drop-jump protocol and for at least 16 hours per day (approximately 8 hours waking and 8 hours overnight) for 72 hours; removed for each muscle function assessment and for washing and personal care.
Non-infused control garment
Other interventionSocks and leggings identical in appearance, fabric construction, sizing and packaging to the active garment but manufactured without the mineral infusion. Same issue quantity and wear schedule as the active garment.
Muscle-damaging eccentric exercise (drop jumps)
Other intervention100 drop jumps performed as 5 sets of 20 repetitions from a standardised box height with standardised landing technique, 10 seconds between jumps and 2 minutes between sets, under one-to-one supervision on Day 1. Used as the experimental model of exercise-induced muscle damage in both arms.
Treatment groups
52 Participants
are divided into 2 treatment groupsGroup A: Mineral-infused garmentExperimental treatment 2 interventions
Group B: Non-infused control garmentSham comparator 2 interventions
Trial outcomes
Primary outcomes
1
Change in maximal voluntary isometric contraction (MVC) force of the knee extensors at 72 hours post-exercise
Peak isometric force of the knee extensors of the dominant limb measured by fixed-frame dynamometry, expressed as a percentage of the participant's pre-exercise baseline value.
Time frame
Pre-exercise baseline and 72 hours post-exerciseSecondary outcomes
1
Change in maximal voluntary isometric contraction (MVC) force of the knee extensors at 0, 24 and 48 hours post-exercise
Peak isometric force of the knee extensors of the dominant limb measured by fixed-frame dynamometry, expressed as a percentage of pre-exercise baseline.
Time frame
Pre-exercise baseline and 0, 24 and 48 hours post-exercise2
Change in squat jump peak force
Bilateral peak force during a maximal squat jump measured on a dual force plate system, expressed relative to pre-exercise baseline.
Time frame
Pre-exercise baseline and 0, 24, 48 and 72 hours post-exercise3
Change in perceived muscle soreness (delayed onset muscle soreness)
Muscle soreness rated on a 100 mm visual analogue scale (0 mm = no soreness, 100 mm = worst soreness imaginable; higher scores indicate a worse outcome) immediately after a single bodyweight squat to a fixed box height.
Time frame
Pre-exercise baseline and 0, 24, 48 and 72 hours post-exercise4
Garment tolerability: number of participants with garment-related skin reactions or adverse events
Skin under the garment is visually inspected at each visit and any redness, irritation, pressure marking, swelling or broken skin is graded as none, mild, moderate or severe. Garment comfort and tolerability are also reported by participants in the Study Exit Questionnaire.
Time frame
From Day 1 (garment issue) to 72 hours post-exerciseOther outcomes
1
Change in blood creatine kinase concentration
Creatine kinase (IU/L) measured from finger-prick capillary blood samples analysed by a UKAS-accredited laboratory (Inuvi Health Ltd). Log-transformed for analysis and reported as geometric mean ratios.
Time frame
Pre-exercise baseline and 24, 48 and 72 hours post-exercise2
Relationship between total garment wear time and recovery of MVC force at 72 hours
Total garment wear hours across the 72-hour recovery period (from the participant's daily wear log) entered as a continuous covariate, with treatment group and the wear-by-group interaction, in a model of MVC force at 72 hours expressed as a percentage of baseline.
Time frame
Day 1 to 72 hours post-exercise Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: