Minimally Invasive Non-Surgical Periodontal Treatment
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorAtaturk University
About this trial
This single-center, split-mouth, randomized controlled clinical trial aims to evaluate the clinical effectiveness of Minimally Invasive Non-Surgical Therapy (MINST) as an adjunct to conventional non-surgical periodontal therapy in patients with Stage III/IV periodontitis. Twenty-three systemically healthy adults presenting with bilateral molar teeth exhibiting periodontal pockets ≥5 mm with bleeding on probing will be enrolled. In each participant, molar teeth will be randomly allocated to receive either conventional subgingival scaling and root planing (SRP) using ultrasonic instruments alone (control) or conventional SRP followed by MINST using Mini-Five Gracey curettes under magnification loupes (test). Clinical periodontal parameters, including Plaque Index (PI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL), will be evaluated at baseline, 3 months, and 6 months after treatment. The study will investigate whether MINST provides superior clinical outcomes compared with conventional non-surgical periodontal therapy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adults aged 18 to 35 years.
Diagnosed with Stage III or Stage IV periodontitis.
Systemically healthy.
Presence of at least two bilateral molar teeth with probing pocket depth (PPD) ≥5 mm and bleeding on probing (BOP).
Disqualifiers
Individuals who do not meet the inclusion criteria.
Pregnancy or breastfeeding.
Presence of systemic diseases or medical conditions affecting periodontal status or healing.
Current use of medications that may influence periodontal healing.
Trial design
Design model
Crossover
Treatments tested in this trial
Minimally Invasive Non-Surgical Therapy (MINST)
Procedure/SurgeryMinimally Invasive Non-Surgical Therapy (MINST) consists of subgingival scaling and root planing performed using Mini-Five Gracey curettes under ×4.0 magnification loupes following conventional ultrasonic instrumentation. The procedure is designed to minimize soft tissue trauma while improving access to deep periodontal pockets and root surface debridement. Treatment is completed in two sessions separated by one week.
Conventional Scaling and Root Planing
Procedure/SurgeryConventional non-surgical periodontal therapy consisting of subgingival scaling and root planing performed using ultrasonic instruments. Treatment is completed over two sessions separated by one week according to the study protocol.
Treatment groups
23 Participants
are divided into 2 treatment groupsGroup A: MINST GroupExperimental treatment 1 intervention
Group B: Conventional SRP GroupActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Probing Pocket Depth (PPD)
Change in probing pocket depth (PPD) measured in millimeters using a UNC-15 periodontal probe.
Time frame
Baseline, 3 months, and 6 monthsSecondary outcomes
1
Clinical Attachment Level (CAL)
Change in clinical attachment level (CAL) measured in millimeters using a UNC-15 periodontal probe.
Time frame
Baseline, 3 months, and 6 months2
Bleeding on Probing (BOP)
Change in bleeding on probing (BOP).
Time frame
Baseline, 3 months, and 6 months3
Plaque Index (PI)
Change in Plaque Index (PI).
Time frame
Baseline, 3 months, and 6 months4
BANA Test
Changes in subgingival microbial profile assessed using the benzoyl-DL-arginine naphthylamide (BANA) assay.
Time frame
Baseline, 3 months, and 6 monthsSponsors and contacts
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Source ClinicalTrials.gov
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