Mirror vs Virtual Reality Therapy for Upper Extremity Function in Hemiplegic Patients

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorIstinye University

About this trial

Upper extremity impairment in hemiplegic patients significantly impacts daily activities and reduces quality of life. Although traditional rehabilitation methods can help, some patients experience limited progress. Recently, modern techniques such as mirror therapy and virtual reality (VR) have emerged, demonstrating promising results in motor skill improvement.

This study aims to directly compare the acute effects of mirror therapy and VR therapy on upper limb motor function in hemiplegic patients. Forty-two participants aged 18-75 with hemiplegia due to stroke (6-12 months post-stroke) will be randomly assigned to either mirror therapy or VR therapy. The evaluation includes motor function (Fugl-Meyer Assessment), spasticity (Modified Ashworth Scale), activities of daily living (Barthel Index), fine motor skills (Box and Block Test), proprioception, and reaction time.

The goal is to identify the effectiveness of the mirror therapy and VR therapy on motor function, spasticity control, proprioception, daily activity performance, and reaction times, contributing valuable insights to clinical rehabilitation practices.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Hemiplegic patients in need of upper extremity rehabilitation.

Having had a stroke 6 to 12 months prior to the study.

Being at least Stage 3 for the upper extremity according to the Brunnstrom motor recovery stages.

Age range: between 18 and 75 years.

Disqualifiers

Patients with severe spasticity (score ≥ 3 on the Modified Ashworth Scale)

Individuals with secondary neurological conditions (e.g., Parkinson's disease, multiple sclerosis).

Individuals diagnosed with vestibular dysfunction (as virtual reality equipment may cause issues like nausea or dizziness).

Individuals with communication issues, such as hearing or vision loss.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Mirror Therapy

    Other intervention

    Mirror therapy will be applied to the affected upper extremity by placing a mirror in the midsagittal plane to reflect movements of the non-paretic limb, creating the visual illusion of symmetrical bilateral movement. Participants will perform task-specific functional movements of the hand and arm (e.g., grasping, wrist flexion, and extension) while focusing on the mirror image.

  • Virtual Reality (VR) Therapy

    Device

    Virtual reality therapy will be delivered using the Meta Quest 2 head-mounted display system. Participants will engage in interactive, task-specific upper extremity exercises designed to promote motor activation and functional movement of the affected limb through immersive visual feedback.

Treatment groups

42 Participants
are divided into 2 treatment groups
Group A: Mirror TherapyExperimental treatment 1 intervention
Group B: Virtual Reality (VR) TherapyExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Fugl-Meyer Assessment for Upper Extremity (FMA-UE)

The Fugl-Meyer Assessment is a standardized and widely used tool designed to evaluate motor function, balance, sensation, and joint functioning in individuals with post-stroke hemiplegia. In this study, only the upper extremity motor domain will be used, which includes evaluation of movement, coordination, and reflex action of the shoulder, elbow, forearm, wrist, and hand. The assessment is scored on a 3-point ordinal scale: 0 (cannot perform), 1 (performs partially), and 2 (performs fully), with a maximum score of 66 indicating better motor recovery. Participants are seated or lying in a comfortable position during the test, and each movement is explained and demonstrated. The researcher scores the quality and completion of each movement. The FMA-UE is a valid and reliable measure of motor function and is widely used in stroke rehabilitation research

Time frame
Day 1
2

Box and Block Test (BBT)

The Box and Block Test (BBT) is a standardized assessment of unilateral gross manual dexterity. Participants are instructed to transfer as many wooden blocks as possible from one compartment of a box to the other within 60 seconds using one hand. The number of successfully transferred blocks is recorded as the score. The test is widely recognized for its simplicity, reliability, and sensitivity in detecting changes in motor function, especially in post-stroke patients. In this study, the BBT will be used to evaluate changes in upper extremity motor performance and coordination immediately before and after the intervention session.

Time frame
Day 1

Secondary outcomes

1

Modified Ashworth Scale (MAS)

The Modified Ashworth Scale (MAS) is used to assess muscle spasticity by measuring resistance during passive soft-tissue stretching. It is a reliable clinical tool commonly used in neurological rehabilitation settings, especially in stroke patients. During the assessment, the target limb is passively moved through its range of motion, and the resistance to movement is rated on a 6-point scale ranging from 0 (no increase in muscle tone) to 4 (affected part rigid in flexion or extension). Participants are placed in a neutral and relaxed position during testing to ensure consistency. The evaluation will be conducted on the upper extremity muscles involved in voluntary function, and changes in MAS scores will be recorded to determine immediate effects of the intervention on spasticity levels.

Time frame
Day 1
2

joint Position Sense Test (Proprioception Assessment)

The Joint Position Sense Test assesses proprioceptive accuracy by evaluating a participant's ability to replicate specific joint angles with the opposite limb while blindfolded or with eyes closed. For this study, the test involves passive positioning of the affected upper limb at predetermined target angles (e.g., 60° and 100° of shoulder flexion), which participants will then attempt to match with the contralateral limb. The difference in angle reproduction is used as a measure of proprioceptive acuity. This method provides insight into sensorimotor integration deficits common in hemiplegic patients and will be used to assess changes before and after the intervention

Time frame
Day 1
3

Simple Reaction Time (SRT) with BlazePod

Simple Reaction Time (SRT) is a measure of how quickly an individual responds to a single stimulus. In this study, SRT will be evaluated using BlazePod light pods, which emit visual cues in a random sequence. Participants, seated comfortably with their hands resting near the pods, will be instructed to tap the lit pod as quickly as possible upon activation. The device records the reaction time in milliseconds. This test provides valuable information about the efficiency of sensorimotor integration and central processing speed. It is particularly relevant in stroke rehabilitation, where improvements in reaction time often correlate with better functional recovery.

Time frame
Day 1
4

Global Rating of Change (GRC) scale

The Global Rating of Change (GRC) scale is a subjective measure used to evaluate a patient's perceived improvement or deterioration in their health status over time. It is particularly useful in musculoskeletal and neurorehabilitation studies. In this study, participants will be asked to compare their current condition to their pre-treatment condition immediately after the therapy session. The version used includes a 5-point Likert scale ranging from -2 to +2, where: -2 = much worse, -1 = slightly worse, 0 = no change, +1 = slightly better, and +2 = much better. This simple, patient-centered outcome allows us to capture overall satisfaction and perceived effectiveness of the therapy from the patient's perspective.

Time frame
Day 1

Other outcomes

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