Mitochondrial Function After Ketamine
ConditionMajor Depressive Disorder
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorSheba Medical Center
About this trial
The goal of this observational study is to learn about the role of mitochondria in response to S-ketamine. in individuals with Treatment-Resistant Depression.
the Research Questions are
1. Does S-ketamine treatment modulate mitochondrial function in peripheral blood cells, as reflected by mitochondrial content and circulating mitochondrial biomarkers such as GDF15? 2. Can changes in mitochondrial function serve as biomarkers for predicting or monitoring clinical response to S-ketamine treatment?
Samples will be collected at baseline, 3 hours after the first treatment, and 6 weeks post-exposure, and compared between responders and non-responders
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
None
Trial population
We will recruit ten normal controls, 30 Patients with the diagnosis of treatment-resistant depression (TRD), failed to at least two antidepressants
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
S (+) Ketamine
Drugthe patients are treated with S-Ketamine in order to treat there Treatment-Resistant Depression via inhalation
Treatment groups
30 Participants
are divided into 1 treatment groupGroup A: Ketamine inhalation group1 intervention
Trial outcomes
Primary outcomes
1
S-ketamine effects on the mitochondrial
Does S-ketamine treatment modulate mitochondrial function in peripheral blood cells, as reflected by mitochondrial content and circulating mitochondrial biomarkers such as GDF15?
Time frame
3 hours and 6 weeksOther outcomes
1
mitochondrial function as a biomarker for S-ketamine treatment
Can changes in mitochondrial function serve as biomarkers for predicting or monitoring clinical response to S-ketamine treatment
Time frame
3 hours and 6 weeksSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: