MMP-2/3 and Periapical Healing Outcomes
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorTC Erciyes University
About this trial
This prospective randomized clinical study will investigate the association between MMP-2 and MMP-3 gene polymorphisms and radiographic healing outcomes following nonsurgical root canal treatment in patients with chronic apical periodontitis. A total of 50 patients will undergo standardized endodontic treatment and will be followed for 12 months. Genotyping will be performed using baseline DNA samples, and periapical healing will be assessed using the Periapical Index (PAI). The relationship between genetic variations and treatment outcomes will be analyzed to determine whether host-related genetic factors influence healing patterns after root canal therapy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Single-rooted teeth
PAI score ≥ 3
Fully developed root apices
Periodontal probing depth less than 5 mm
Disqualifiers
Previous endodontic treatment in the selected tooth
Diagnosis of symptomatic apical abscess
Presence of root fracture or internal/external resorption
Use of systemic antibiotics within the previous 4 weeks
Trial population
The study population will consist of adult patients aged 18-65 years diagnosed with chronic apical periodontitis in single-rooted teeth and requiring primary nonsurgical root canal treatment. All participants will be classified as ASA I or II and will be recruited from patients referred to the Department of Endodontics. Only individuals meeting the predefined inclusion and exclusion criteria will be enrolled. Participants will undergo standardized treatment and follow-up under controlled clinical conditions.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Nonsurgical Root Canal Treatment
Procedure/SurgeryAll participants will undergo standardized nonsurgical root canal treatment performed under a uniform clinical protocol. After local anesthesia and rubber dam isolation, working length will be determined electronically and radiographically. Root canal preparation will be completed with rotary instrumentation up to size 30/.06, accompanied by sodium hypochlorite irrigation, EDTA, and ultrasonic activation. Canals will then be obturated in the same visit using gutta-percha and epoxy resin-based sealer with the warm vertical condensation technique. Periapical healing outcomes at 12 months will be evaluated in relation to MMP-2 and MMP-3 genetic polymorphisms.
Treatment groups
50 Participants
are divided into 1 treatment groupGroup A: Standardized Root Canal Treatment1 intervention
Trial outcomes
Primary outcomes
1
Radiographic Periapical Healing
The primary outcome will be radiographic healing assessed using the Periapical Index (PAI) scoring system on standardized periapical radiographs.
Time frame
12 months after treatmentSecondary outcomes
1
Association Between MMP Genotypes and Healing Outcomes
The association between MMP-2 (rs243865) and MMP-3 (rs3025058) genotypes and radiographic healing outcomes will be evaluated. Genotype and allele distributions will be compared between healed and non-healed groups to determine the potential influence of genetic polymorphisms on periapical healing following root canal treatment.
Time frame
Baseline (genotyping) and 12 months after treatmentLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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