About this trial
The aging of China's rural population is severe, with both the prevalence and mortality rates of dementia higher in rural areas than in urban areas. Motor Cognitive Risk Syndrome (MCR), as a novel pre-dementia syndrome characterized by both subjective cognitive decline and slow gait, represents a "golden window of opportunity" for the early prevention and treatment of dementia. Currently, there is no specific pharmacological treatment for MCR; non-pharmacological interventions, particularly exercise interventions, are key strategies. Moderate-intensity aerobic calisthenics, which integrates music, dance, and gymnastic elements, is economical, simple, highly engaging, safe, and has demonstrated potential for improving both cognitive and gait function, making it especially suitable for promotion in resource-limited rural settings. However, there is a lack of systematic, theory-guided exercise intervention protocols and effectiveness validation for rural older adults with MCR. Therefore, this study aims to develop and validate a moderate-intensity aerobic calisthenics intervention protocol tailored to this population.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age ≥60 years;
Meeting the diagnostic criteria for Motor Cognitive Risk Syndrome (MCR);
Clear consciousness and ability to communicate clearly;
Permanent residents of rural areas in nine prefecture-level cities of Fujian Province (with an annual residence of ≥9 months) and no plan to relocate within the next year; -⑤ Willing to voluntarily participate and sign the informed consent form.
Disqualifiers
Presence of severe mental disorders, history of stroke, Parkinson's disease, or severe visual/auditory impairments;
Physical disability that prevents independent walking;
Comorbid severe systemic diseases, such as cardiopulmonary conditions; -④ Regular exercise habits within the past 6 months (≥30 minutes/day, ≥3 days/week) or a long-term history of exercise; -⑤ Current participation in other interventional studies.
Trial design
Parallel
Treatments tested in this trial
moderate-intensity aerobic exercise
Other interventionBased on routine health education, the intervention group receives a 12-week moderate-intensity aerobic exercise intervention (Jiamusi Happy Dance Steps) lasting 60 minutes per session, three times per week, delivered in a group setting, followed by a 12-week follow-up period.
Routine Care
Other interventionWhile maintaining daily living habits unchanged, provide knowledge related to health education for Motor Cognitive Risk Syndrome (MCR) and receive the MCR health education manual.
Treatment groups
Trial outcomes
Primary outcomes
Montreal Cognitive Assessment Basic
The MoCA-B was jointly developed by the Montreal Cognitive Assessment Clinic and Research Institute in Canada, in collaboration with the Prince Mahidol Award Foundation of Thailand and the Faculty of Medicine at Chulalongkorn University. It has a total score of 30 points and encompasses eight cognitive domains: executive function, language, orientation, calculation, abstract thinking, memory, visual perception, and attention, with higher scores indicating better cognitive function. The cutoff values are as follows: for years of education ≤6 years, MoCA-B ≥20; for 6 years \< years of education ≤12 years, MoCA-B ≥23; and for years of education \>12 years, MoCA-B ≥25. The scale correctly identifies cognitively normal participants with a specificity of 86%, and demonstrates a sensitivity of 81% for detecting cognitive impairment. The Cronbach's α coefficient of the scale is 0.807, and the criterion valid
Walking speed
The timed walking test was used to measure gait speed. The required equipment included a tape measure and a stopwatch. The specific procedure was as follows: First, a straight 6-meter course was measured using the tape measure, and the middle 4-meter segment was marked. The participant stood at the starting point. Then, upon the tester's command "Start," the participant walked at their normal pace to the endpoint. The time taken to cover the middle 4 meters was recorded using the same stopwatch. This was performed twice. Finally, gait speed was calculated using the formula speed = distance / time, with the average time of the two trials used for calculation.
Secondary outcomes
Subjective Cognitive Decline-questionnaire 9
The SCD-Q9 was adapted and revised into Chinese by Hao Lixiao et al. It encompasses two dimensions: global memory ability with time comparison, and activities of daily living. It primarily assesses memory, recall ability, language ability, attention, orientation, and other domains. The questionnaire consists of 9 items. The scoring reference criteria for item responses are as follows: "Yes" = 1 point, "No" = 0 points, "Often" = 1 point, "Occasionally" = 0.5 points. The total score ranges from 0 to 9 points, with higher scores indicating a greater likelihood of cognitive impairment. A score of ≥5 points suggests the possible presence of potential memory impairment.
short physical performance battery
The Short Physical Performance Battery (SPPB), developed by the National Institute on Aging (NIH), objectively assesses balance, lower limb strength, and physical function in older adults. Originally designed to predict disability, institutionalization, or mortality, it is now widely used for frailty, fall risk, and disease-related functional impairment. The SPPB includes three tests: balance, 4-meter gait speed, and five-repetition sit-to-stand, each scored 0-4, total 0-12 (higher = better function). Scores 0-3: severe mobility limitation with daily living difficulties; 4-6: mild limitation, needing assistance or aids; 7-9: normal mobility, independent in daily activities; 10-12: excellent mobility, robust and strong.
Handgrip strength
A electronic hand dynamometer (CAMRY, USA) was used to assess the upper limb muscle strength of the participants. Before measurement, the staff adjusted the dynamometer to zero. During the test, the participant stood in a natural posture with both arms hanging naturally at the sides. The dynamometer was kept as suspended as possible without touching the body, while maintaining the device stable. The participant was instructed to relax and then squeeze the dynamometer forcefully with the dominant hand three times (with an interval of \>15 seconds between each attempt). The maximum value among the three attempts was recorded as the grip strength.
Body fat
Body composition was assessed using bioelectrical impedance analysis (BIA) with an InBody H20N body fat scale, primarily measuring muscle and fat-related parameters. Before testing, participants wore light clothing without metal accessories and removed metal items such as watches, rings, and necklaces. During testing, participants stood barefoot on the metal electrode plates with feet shoulder-width apart, ensuring close contact of heels and forefeet with the plates. They held the handles on both sides with arms hanging naturally, hands dry and not touching the trunk. The operator initiated the measurement, during which participants remained still, silent, and motionless. The measurement lasted 1-2 minutes, and the device introduced a low-intensity electrical current to determine bioelectrical impedance parameters and estimate body composition.
Sponsors and contacts
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Fujian Provincial Hospital
Lead sponsor
Fujian Medical University
Sponsor institution
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