Health TrialsbyHealthPanel

Modulating Movement Intention Via Cortical Stimulation

ConditionsSeizuresSeizure DisorderPsychogenic Movement Disorder
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorNYU Langone Health

About this trial

The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies. These results could provide preliminary data for subsequent studies evaluating local and global efficacy of plasticity-inducing treatments for PMD symptoms.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Fluent in English

Diagnosis of PMD/PNES confirmed by a neurologist with expertise in movement disorders.

Per the treating neurologist, subject is unlikely to require treatment and/or dosage changes for 3-6 months following screening

Disqualifiers

Any history of a significant neurological disorder, which may interfere with the interpretation of study data, as determined by the PI

Chronic or progressive medical condition

Any history of traumatic brain injury or significant head trauma

Currently meets criteria for substance abuse or dependence

Trial design

Design model

Parallel

Treatments tested in this trial

  • Sham TMS3 stimulation

    Device

    half of the subjects will receive sham stimulation first

  • rTMS of left or right angular gyrus (AG) or frontal cortex (FC)

    Device

    Half of the subjects will receive active stimulation first; A subject may receive either TMS or tDCS stimulation, but not both, over the course of the sub-study.

  • Anodal tDCS of left or right AG or FC

    Device

    Half of the subjects will receive active stimulation first; A subject may receive either TMS or tDCS stimulation, but not both, over the course of the sub-study.

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: Healthy PatientsActive comparator 3 interventions
Group B: PMD/PNES patientsActive comparator 3 interventions

Trial outcomes

Primary outcomes

1

Changes in signal intensity measured using of tDCS

as a result of altering cerebral perfusion in response to neurophysiologic stimulation

Time frame
30 Minutes
2

Changes in signal intensity measured during EEG recording

as a result of altering cerebral perfusion in response to neurophysiologic stimulation

Time frame
3 Hours
3

Changes in signal intensity measured during MEG

as a result of altering cerebral perfusion in response to neurophysiologic stimulation

Time frame
3 Hours

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

NYU Langone Health

Lead sponsor

Source ClinicalTrials.gov
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