Molecular Autopsy Study
ConditionSudden Unexplained Death
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeUp to 45
SponsorScripps Translational Science Institute
About this trial
This study seeks to incorporate genetic testing into the postmortem examination of cases of sudden unexplained death.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Index case age between birth - 45 years
Clinical presentation of sudden / unexplained death (believed to be cardiac in nature OR secondary to a massive unprovoked pulmonary embolism with no prior diagnosis of prothrombotic disease)
Disqualifiers
Premature death secondary to murder, suicide or external causal event
Premature death thought secondary to known chronic comorbid medical condition
Premature death thought secondary to end-organ failure (kidney, liver, lung) other than heart
Previously diagnosed with hypertrophic cardiomyopathy (HCM)
Trial population
The study population is limited to cases of sudden unexplained death in San Diego County and their living, biologically-related family members.
Trial design
Design model
Case-only
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
100 Participants
are grouped into 2 trial groupsGroup A: Index case
Group B: Biologically related family member
Trial outcomes
Primary outcomes
1
Heritable causes of sudden death
The primary endpoint for this study is the discovery of genomic information that may help identify a potential cause of death in the index case. This information may inform living, biologically related family members of their potential risk and need for further genomic analysis.
Time frame
3 yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov