The purpose of this retrospective and prospective project is to understand the molecular and genetic basis of liver cancer of childhood. Understanding the molecular and genetic bases of liver cancers can offer a better classification based on tumor biology, mechanisms and predisposition.
Prior or current treatment for a childhood liver tumor, malignant or benign, at age <21 years.
Biological parents and siblings of eligible children.
No prior or current treatment for a childhood liver tumor.
Non-biological parents, legal guardians, or non-biological siblings of eligible children.
Living or deceased individuals who were diagnosed with a liver tumor, malignant or benign, during childhood (age \<21 years) and their biological parents and siblings.
Other
Other
Not listed
Gene sequencing
DNA sequence variants
Gene expression analysis
Differentially expressed genes
Status of genome-wide chromatin accessibility
chromatin accessibility
Epigenetic change
Differential methylation
Response to chemotherapy
Survival
Response to chemotherapy
Relapse
Click on the lead sponsor to view all of their trials.
