Although considered a rare disease, Biliary Atresia (BA) is the leading cause of neonatal cholestasis and liver transplantation in children. Little is known about the molecular mechanisms that drive BA. The purpose of this study is to collect the fluid samples, explanted liver tissue samples and dermal biopsy samples to enable investigators to perform the genetic and molecular analyses that might point to the gene(s) and cellular pathway involved in etiology of BA disease.
confirmed diagnosis of biliary atresia in patients
parents of BA patients
no
Single group
blood sampling
Other interventioncollection of blood sample for preparation of DNA
skin biopsy sampling
Other interventionpreparation of primary cultures of dermal fibroblasts from skin biopsy sample
explanted liver of BA patients sampling
Other interventioncryoconservation of liver tissue for molecular analyses
To identify the molecular mechanisms implicated in the etiology of BA
To identify gene(s) and cellular pathways affected in cells and liver tissue of BA patients: sequencing experiments
Click on the lead sponsor to view all of their trials.
