This is a biological study for adult MDS patients who undergo HSCT procedure. Viable bone marrow samples will be collected and cryopreserved from MDS patients before transplantation and at clinical disease recurrence. CD34+ blast cells at disease relapse after HSCT will be compared with CD34+ cells collected before transplant to study genomic and transcriptomic changes.
Diagnosis of MDS according to 2016 WHO criteria
Aged 18y or older
Patients who will receive allogeneic stem cell transplantation (HSCT)
Signed written informed consent according to ICH/EU/GCP and national local laws
Second HSCT procedure.
Single group
bone marrow withdrawal
Other interventionbone marrow samples evaluation
CD34+ blast cells modifications
Difference in frequency distribution of CD34+ blast cells mutations between transplant and relapse.
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