Molecular Optimization Via Exercise (MOVE)
ConditionAging
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age65-80
SponsorBuck Institute for Research on Aging
About this trial
This study is to investigate characteristics of muscle, blood, and urine samples from older adults (ages 65-80) who are either sedentary or athletes performing at an elite level for their age. This observational study will include bio-specimen collection, as well as physical and cognitive function testing and body composition.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Willing and able to provide consent to take part in the MOVE-1 Main Study.
Willing and able to attend study visits and comply with all procedures of study data collection visits.
Able to read and speak English well enough to provide informed consent and understand instructions.
Healthy adults between the age of 65 - 80 y.
Disqualifiers
Subject requires assistance with any activity of daily living, excluding continence.
Subject lives in an institutional setting (skilled nursing facility or residential care facility for the elderly).
Abnormal bleeding or coagulopathy (self-report): History of a bleeding disorder, wound healing disorder or clotting abnormality.
Female participants must be post-menopause.
Trial population
Male and female Older Endurance Athletes (OEA) at/over the age of 65 - 80 y (exercising at an elite level for their age - assessed by interview and review of training data and competition/results) Male and female Healthy Older Adults (HOA) at/over the age of 65 -80 y who do not regularly exercise (no more than one day per week lasting no more than 60 mins of regular structured exercise)
Trial design
Design model
Cohort
Time perspective
Cross-sectional
Treatments tested in this trial
Observational
Other interventionNo intervention
Treatment groups
80 Participants
are divided into 2 treatment groupsGroup A: Group 1 cohort: Healthy Older Adults (HOA)1 intervention
Group B: Group 2 cohort: Elite Older Athletes (EOA)1 intervention
Trial outcomes
Primary outcomes
1
Muscle cellular aging - spatial transcriptomics
Differences between athletes and sedentary in muscle spatial transcriptomic between OEA and HOA groups
Time frame
Day 22
Muscle cellular aging - single cell transcriptomics
Differences between athletes and sedentary in muscle single cell transcriptomic between OEA and HOA groups
Time frame
Day 2Secondary outcomes
1
Differences between concentration of proteins in the muscle
Proteomic analysis to measure differences in protein abundance in EOA vs HOA
Time frame
Day 22
Differences between concentration of metabolites in the muscle
Metabolomic analysis to measure differences in metabolite abundance in EOA vs HOA
Time frame
Day 23
Differences between function of muscle mitochondria
Analysis of respiratory function of isolated mitochondria
Time frame
Day 24
Blood metabolites
Metabolic analysis: differences between athletes and sedentary in blood metabolites
Time frame
Day 2Other outcomes
1
Body composition - BIA
Body composition measured by bioelectrical impedance
Time frame
Day 12
Body composition - muscle mass
Total muscle mass measured by D3 creatine supplement followed by urine collection
Time frame
Day 23
Cognitive function - Montreal Cognitive Assessment
Paper and interview based test that measures multiple domains of function
Time frame
Day 14
Cognitive function - digit symbol substitution
Paper based test that involves matching symbols and numbers in a set time.
Time frame
Day 1Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov