Patients will be asked to visit the study center 2 times, the first time for clinical assessment and a second time for sample collection. Healthy controls will only be asked to visit the study center for sample collection. A sample of blood and saliva will be collected in order to measure CGRP levels and DNA and hormone testing.
Migraine patients according to ICHD-3 criteria
Healthy controls paired to patient age and sex, without headache and without first degree family history of headache.
Presence of any major medical or neurological illness.
Presence of any salivary gland malfunction.
Abuse or dependence to tobacco, alcohol or any drug in the previous 12 months before the enrollment.
Active migraine preventive treatment.
Males and females otherwise healthy with episodic and chronic migraine in different age groups will be included in the study. Controls matching age and sex will be selected for the control groups.
Case-control
Prospective
Saliva test
Diagnostic testSampling of CGRP in saliva and DNA blood test and sex hormones blood test.
CGRP level
Measure of CGRP in saliva
Hormone levels
Blood test to quantify female hormones (FSH, LH, estradiol, progesterone, prolactin) and male hormones (testosterone) in all participants except for prepubertal children.
DNA test
DNA testing for CGRP or its receptor related genes (CALCA, CALCB, CALCRL and RAMP1)
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