Molecular Pituitary Imaging Using 18F-FET PET

ConditionPituitary Adenoma

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-100

SponsorUniversity of Cambridge

About this trial

The goal of this single centre pilot study is to explore whether 18F-fluoro-ethyl-tyrosine PET (FET-PET) yields comparable findings to 11C-methionine PET (Met-PET) for the localisation of pituitary tumours.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Participant is willing and able to give informed consent for participation in the study

Male or female, age 18 or above

Presence of pituitary adenoma suspected on the basis of clinical/biochemical and/or radiological findings

Previous 11C-Met-PET/CT

Disqualifiers

Inability to give informed consent

Pregnancy or suspected pregnancy

Inability to lie supine for 30-60 minutes

Patient body habitus above scanner dimensions

Trial design

Design model

Single group

Treatments tested in this trial

18F-Fluoro-ethyl-tyrosine (FET) PET
Diagnostic test
18F-Fluoro-ethyl-tyrosine PET study of the pituitary

Treatment groups

20 Participants

are divided into 1 treatment group

Group A: Study cohortExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Maximum Standardized Uptake Values (SUVmax) over pituitary tumour on each of 11C-methionine and 18F-fluoroethyltyrosine PET scans

Comparison of maximum Standardized Uptake Values (SUVmax) measured over pituitary tumours on each type of PET scan.

Time frame

1 day

Secondary outcomes

Maximum Standardized Uptake Values (SUVmax) over normal pituitary gland and parasellar structures (e.g. cavernous sinuses) on each of 11C-methionine and 18F-fluoroethyltyrosine PET scans

Comparison of maximum Standardized Uptake Values (SUVmax) measured over normal pituitary gland and parasellar structures (e.g. cavernous sinuses) on each type of PET scan.

Time frame

1 day

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Cambridge

Lead sponsor

Cambridge University Hospitals NHS Foundation Trust

Collaborator

Source ClinicalTrials.gov

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