MOLyF : Bone Marrow and Follicular Lymphoma
ConditionLymphoma, Follicular
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorRennes University Hospital
About this trial
This is a prospective single-center study designed to assess potential differences in cell composition between bone marrows of patients with follicular lymphoma and those from control subjects.
Follicular lymphoma is the most common indolent lymphoma. It is characterised by systematic relapses and bone marrow dissemination in 70% of patients at the time of diagnosis.
Although relapses are thought to be related to refractory tumour cells nested in a supportive microenvironment in the bone marrow, the mechanisms involved are poorly understood.
To study the specificities of the bone marrow of patients with follicular lymphoma, It is necessary to compare them with control samples.
This study takes advantage of surgeries involving sternotomies to recover lost bone marrow and establish a bone marrow bank of patients without hematological disease.
This bank will be used to set up control cohorts for other clinical trials involving patients with follicular lymphoma.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Major patient
Patient hospitalized in the thoracic, cardiac and vascular surgery department for surgery involving a sternotomy
Patient with free, informed, written consent
Patient covered by a health insurance scheme
Disqualifiers
History of haematological malignancy or haemogram disturbance
Immunomodulating treatment: immunosuppressants, corticoids, antineoplastics
Persons covered by articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French Public Health Code (e.g. minors, protected adults, etc.)].
Trial design
Design model
Single group
Treatments tested in this trial
Sampling
Other interventionsternal bone marrow aspiration
Treatment groups
200 Participants
are divided into 1 treatment groupGroup A: ExperimentalExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Flow cytometric quantification of cell populations
Bone marrow cell populations of lymphoma-free patients (lymphoid cells, myeloid cells, stromal cells and adventitial cells) will be quantified using a flow cytometry panel and compared with those of Follicular Lymphoma patients.
Time frame
1 daySponsors and contacts
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Source ClinicalTrials.gov