Monetary Incentive Delay Task for Probing Reward-related Neural Processes
ConditionAdolescent Development
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age14-17
SponsorStony Brook University
About this trial
150 males and 150 females ages 14-17 years-old will be enrolled in an observational, longitudinal study. There are three planned in-person visits: a baseline assessment, an 18-month follow-up, and a 36-month follow-up. The in-person visits will include assessment of substance use and other individual differences (e.g., reward function, psychiatric history), neuromelanin-sensitive MRI, as well as functional brain activation collected while the participant is at rest (resting-state fMRI) and while the participant completes a Monetary Incentive Delay task. Subjects will also be asked to complete past 90-day substance use assessments remotely every 90 days for 36 months.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Males and females ages 14-17 years-old;
English-speaking for assent and interview completion;
Capacity to provide assent.
For parents, the inclusion criteria will be willing and capacity to provide parental permission/consent.
Disqualifiers
current (within 6 months) use of medication that may affect cerebral function
history of severe medical or neurological illness, including stroke or seizure;
history of head trauma with loss of consciousness;
presence of metal in the body;
Trial design
Design model
Single group
Treatments tested in this trial
Monetary Incentive Delay Task
Other interventionThe Monetary Incentive Delay functional Magnetic Resonance Imaging task is well-characterized and commonly utilized in research settings to measure neural activation between win and loss conditions, as well as between phases of anticipation and consummation/outcome. A recent meta-analysis indicates that the task has been used in over 80 studies and 5,000 subjects as of Year 2022. The task is also valid and appropriate for use in children and adolescents, as demonstrated by its inclusion in National Institute on Drug Abuse ABCD study. The task is utilized for its short-lived, reversible, and/or benign effects on brain activation (e.g., brief processing of a reward cue).
Treatment groups
300 Participants
are divided into 1 treatment groupGroup A: Whole sampleExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Amount of Brain Activation (BOLD Signal) during Monetary Incentive Delay Task by Condition
fMRI activation during task during win, loss, and no change conditions, as well as anticipation and consummation phases.
Time frame
Baseline, 18-month, 36-month.Sponsors and contacts
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Source ClinicalTrials.gov