Health TrialsbyHealthPanel

Monoamine Oxidase B PET/CT in Various MAO-B-Related Disease

ConditionsParkinson DiseaseParkinson Disease DementiaParkinson's Disease and Parkinsonism
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-90
SponsorTianjin Medical University

About this trial

To evaluate the potential usefulness of 18F-FPyCO/SMBT-1 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various MAO-B-related disease patients.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

patients with non-malignant lesions; (ii) patients with pregnancy; (iii) the inability or unwillingness of the research participant, parent or legal representative to provide written informed consent.

Trial population

(i) adult patients (aged 18 years or order); (ii) patients with suspected or new diagnosed or previously treated PD (supporting evidence may include MRI, CT, tumor markers and pathology report); (iii) patients who had scheduled MAO-B PET/CT scan; (iv) patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the Clinical Research Ethics Committee.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Diagnostic Test: 18F-FPyCO/SMBT-1

    Diagnostic test

    Each subject receive a single intravenous injection of 18F-FPyCO/SMBT-1, and undergo PET/ CT or MRI imaging within the specificed time.

Treatment groups

200 Participants
are divided into 1 treatment group
Group A: Single Group Assignment1 intervention

Trial outcomes

Primary outcomes

1

Standardized uptake value (SUV)

Standardized uptake value (SUV) of 18F-FPyCO/SMBT-1 for each target lesion of subject or suspected PD.

Time frame
30 days

Secondary outcomes

1

Diagnostic efficacy

The sensitivity, specificity and accuracy of MAO-B PET/CT were calculated

Time frame
30 days

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Tianjin Medical University

Lead sponsor

Tianjin Medical University General Hospital

Collaborator

Source ClinicalTrials.gov
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