The present study focuses on patients with Pseudomonas aeruginosa (PSA) sepsis. The aim of the present study is to find out whether the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype predominates in blood monocytes in critically ill patients with PSA-sepsis, and whether the severity of sepsis and outcome is associated with distinct monocyte phenotype and function.
age > 18 years
critically ill patients with sepsis
microbiologically proven infection with Pseudomonas aeruginosa
life expectancy < 24 hours
participation in other studies
Critically ill patients with sepsis with microbiologically proven infection with Pseudomonas aeruginosa
Cohort
Prospective
Not listed
Monocyte surface marker expression in critically ill patients with Pseudomonas aeruginosa sepsis
Monocyte type 1, type 2 surface marker expression
Cytokine concentrations in serum and production after ex-vivo stimulation of isolated monocytes of critically ill patients with Pseudomonas aeruginosa sepsis with LPS
IL-8 and IFN-gamma
Click on the lead sponsor to view all of their trials.
