More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age3+
SponsorUniversity of Erlangen-Nürnberg Medical School

About this trial

In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls. Modern imaging techniques (MRI, MSOT, and echocardiography) as well as questionnaires assessing cardiopulmonary and mental health are used.

Eligibility criteria

Qualifiers

no cancer diagnosis

no lung diseases

no vascular diseases

No subjective reduction in physical performance

Disqualifiers

Pregnancy, Lactation

Known pleural or pericardial effusion

Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure)

Marked thoracic deformities/malformations

Trial design

Treatments tested in this trial

  • QOL assessment, Neuropsychological
  • Spirometry
  • DLCO measurement
  • Echocardioraphy
  • MRI
  • Clinical parameters
  • Blood samples
  • MSOT

Treatment groups

180 Participants
are divided into 3 treatment groups