Mortality and Muscle Mass Loss in Critically Ill Patients.
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorBrno University Hospital
About this trial
The aim of the study is to monitor changes in muscle mass in critically ill patients and to verify whether a decrease in muscle mass of ≥10% during the first 7 days of hospitalization is associated with increased 28-day mortality. We will be used ultrasoud for measurement the rectus femoris cross sectional area.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
age ≥18 years
mechanical ventilation expected for at least 48 hours
Disqualifiers
Clinical Frailty Score above 7 prior admission
Neuromuscular disease in previous medical history
Amputated lower extremities
Trauma of lower extremities involving tights
Trial population
Critically ill adult patients will be admitted to intensive care unit with suspect length of artificial ventilation more than 48 hours.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Relationship between muscle loss and 28 day mortality
Critically ill patients with a ≥10% decrease in rectus femoris cross-sectional area have increased 28 day mortality.
Time frame
28 days after enrollmentSecondary outcomes
1
Incidence of a significant decrease in rectus femoris cross-sectional area
A decrease in rectus femoris cross-sectional area of 10% or more measured by ultrasound.
Time frame
first 7 days of ICU stay2
Incidence of an insignificant decrease in rectus femoris cross-sectional area
A decrease in rectus femoris cross-sectional area of less than 10% measured by ultrasound.
Time frame
first 7 days ICU staySponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: