MRE Evaluation for Spinal Cord Tumor Surgery: Stiffness and Adhesion Assessment
ConditionSpinal Cord Tumors
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorShengjing Hospital
About this trial
In spinal cord tumors requiring surgical intervention, the resection difficulty is determined by two significant factors: tumor stiffness and adhesion to surrounding tissue.
The stiffness of the tumor dictates the complexity of removal, while strong adhesion presents additional challenges during the surgical procedure.
This clinical trial aims to assess the clinical utility of magnetic resonance elastography (MRE), in evaluating the stiffness and adhesion of spinal cord tumors and guiding surgical planning to selecting the most appropriate surgical approach for patients with spinal cord tumors.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
All patients undergoing spinal cord tumor resection surgery are eligible for inclusion in the study cohort.
Disqualifiers
Patients with metallic implants or foreign bodies in their bodies (pacemakers, artificial metallic heart valves, metal joints, metal implants, and those who cannot remove dentures, insulin pumps, or contraceptive rings)
Pregnant women in the first trimester (within three months)
Patients with severe claustrophobia or anxiety
Patients with severe fever
Trial design
Design model
Single group
Treatments tested in this trial
Magnetic Resonance Elastography
Diagnostic testUndergo MRE and routine MRI
Assessment and Recording
Procedure/SurgeryUndergo grading and recording of tumor stiffness and adhesion during surgery
Treatment groups
20 Participants
are divided into 1 treatment groupGroup A: Diagnostic（MRE, tumor grading of stiffness and adhesion）Experimental treatment 2 interventions
Trial outcomes
Primary outcomes
1
Surgical assessment of tumor stiffness
The surgeon will score the tumor stiffness in seven aspects, ranging from 1 to 5 points: Tumor size; Shape of tumor; Tumor texture; Stiffness of the tumor's capsule; Stiffness of the tumor's central region; Primary methods of tumor removal; Features of tumor's capsule.
Time frame
Baseline to 6 weeks2
Surgical assessment of tumor adhesion
The surgeon will score the tumor's adhesion based on seven aspects, ranging from 1 to 4 points: Stripping instruments; Frequency of use of sharp instruments; Adhesion range; Degree of tumor resection; Cranial nerve anatomy preservation; Brain tissue anatomy preservation; Neurological function (compared with preoperative).
Time frame
Baseline to 6 weeksSponsors and contacts
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Source ClinicalTrials.gov