MRI Analysis in the Growth of Cerebral Aneurysms
ConditionUnruptured Intracranial Aneurysm
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCHU de Reims
About this trial
An intracranial aneurysm is defined as a localized dilatation of the cerebral arteries, which can potentially lead to rupture and subsequent hemorrhagic stroke. The mechanisms by which aneurysms develop and grow remain unknown. The objective of this project is to utilize MRI, a routine non-invasive examination for detecting and following up aneurysms, to identify visually and quantitatively an aneurysm growth and relevant biomarkers that can predict the risk of aneurysm development.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients with one or more unruptured intracranial aneurysms followed up at the participating center. Patients may have other ruptured and/or treated aneurysms
Patient older than 18 years
Patient consenting to participate to the study
Patient enrolled in the national healthcare insurance program
Disqualifiers
Patients who have already received surgical or endovascular treatment for all their aneurysm(s), or who are due to receive such treatment in less than 2 months.
Patients with only ruptured aneurysm(s)
Patients with arteriovenous malformations (treated or untreated)
Patients with a contraindication to MRI
Trial design
Design model
Single group
Treatments tested in this trial
Additional 4D Flow MRI or additional 4D Flow sequence
Other interventionAdditional 4D Flow MRI or additional 4D Flow sequence
Treatment groups
281 Participants
are divided into 1 treatment groupGroup A: Patients with unruptured and untreated aneurysmsExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Evolution of the shape of the aneurysm
Millimetric quantification of the three-dimensional evolution of the shape of the aneurysm sac, calculated using a computer algorithm
Time frame
At 3 yearsSponsors and contacts
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Source ClinicalTrials.gov