MRI-changes in Morphometry and Cerebro Spinale Fluid (CSF) Flow in Spinal Cord Disorders

ConditionSpinal Injury

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18-80

SponsorUniversity of Zurich

About this trial

Understanding the onset and progression of spinal cord disorders is an important aim in clinical neurology. An early diagnosis with consequent therapy might prevent the progression of disability. Therefore, we aim to determine structural and dynamic changes in the microstructure of the spinal cord and CSF, and to explore the relationships between the MRI parameters, clinical disability, and electrophysiology.

In some patients that undergo decompressive surgery CSF pressure will be measured invasive perioperative for 24h to find out if functional limitations and structural changes correlate with the spinal pressure and the spinal perfusion when the spinal cord is damaged.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Cervical injury

Informed consent

Age 18-80

CSM

Disqualifiers

No other neurologic disorder and psychiatric disorder

Seizure

MRI incompatibility

Pregnancy

Trial population

Subjects with spinal cord disorder and CSM

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

350 Participants

are grouped into 3 trial groups

Group A: Patients with CSM

Group B: Patients with spinal injury (SCI)

Group C: Healthy controls

Trial outcomes

Primary outcomes

Morphometric changes and changes in cerebro spinal fluid (CSF) flow and spinal cord movement in patients and control subjects will be correlated to functional deficits and neurophysiological data (regression model analysis).

Time frame

Each patient will undergo a MRI scan, clinical and electrophysiological examinations at baseline, after 6 months and after 1, 2, 3, 4, and 5 years. Controls will undergo 1 MRI scan and some scan of retest analysis

Assessment of CSF pressure dynamics in the perioperative setting

Time frame

Perioperative for 24hours

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Zurich

Lead sponsor

Foundation Wings For Life

Collaborator

Balgrist Foundation

Collaborator

Source ClinicalTrials.gov

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