MRI Neurofeedback and Brain Circuits Related to Motivation in Healthy Participants
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorDuke University
About this trial
The purpose of this research study is to understand how healthy individuals self-regulate motivation by observing brain activity using magnetic resonance imaging (MRI).
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age between 18 and 45 years
Right-handed
In good general health
Disqualifiers
Current or diagnosis within past six months of an DSM-V Axis I or Axis II disorder (self-reported)
CES-D score of 20 or higher (indicating significant current depression symptoms)
Current or past six month use of prescription medications indicated for psychiatric conditions (e.g.,depression, anxiety)
Current serious medical illness (self-reported)
Trial design
Design model
Parallel
Treatments tested in this trial
Ventral tegmental area of dopaminergic midbrain (VTA) fMRI neurofeedback
BehavioralfMRI neurofeedback training of sustained midbrain/VTA activation via motivational imagery.
Treatment groups
190 Participants
are divided into 3 treatment groupsGroup A: Intentional Versus Cue-Evoked Midbrain ActivationExperimental treatment 1 intervention
Group B: Intentional Midbrain Activation Effects on Effort-Based Decision MakingExperimental treatment 1 intervention
Group C: Intentional Midbrain Activation Effects on Motivated MemoryExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Percent signal change in VTA BOLD activation
Time frame
During the MRI scan, approximately 2 hoursSecondary outcomes
1
Change in effort-based decision making, as measured by the Effort Expenditure for Reward Task (EEfRT)
Decisions to exert effort.
Time frame
During the MRI scan, approximately 2 hours2
Change in motivated memory, as measured by the Monetary Incentive Encoding task (MIE)
Improved motivated memory formation.
Time frame
During the MRI scan, approximately 2 hoursSponsors and contacts
Click on the lead sponsor to view all of their trials.
Duke University
Lead sponsor
National Institute of Mental Health (NIMH)
Collaborator
Source ClinicalTrials.gov