MRI Role in Knee Hemophilic Arthopathy
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University
About this trial
The aim of this study is to assess role of MRI in detecting synovial, cartilaginous , osseous abnormalities ، bleeding inside knee joint and to use a system for assessing HA as support for therapeutic regimes and for monitoring response to therapy .
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patient ( more than 18 years old ) diagnosed as Haemophilia with history of bleeding in knee joint more than once
Disqualifiers
*contraindications for MRI such as claustrophobia , metallic foriegn body carriers , cardiac pacemaker
patient refused the exam
Pregnant female patients
Trial population
The study population will include patients diagnosed with hemophilia A or hemophilia B who are at risk of, or clinically suspected to have, hemophilic arthropathy of the knee joint. Participants will be recruited from hematology and orthopedic clinics. Eligible participants will undergo knee MRI to assess for: Synovial abnormalities (e.g., hypertrophy, hemosiderin deposition) Cartilaginous changes (thinning, erosions) Osseous changes (subchondral cysts, bone erosions, marrow changes) Intra-articular bleeding MRI scoring systems will be applied to quantify disease severity and to evaluate the role of MRI as a tool for supporting therapeutic decisions and monitoring treatment response.
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
95 Participants
are grouped into 2 trial groupsGroup A: MRI in Knee Hemophilic Arthopathy
Group B: Xray in Knee Hemophilic Arthropathy
Trial outcomes
Primary outcomes
1
International Prophylaxis Study Group (IPSG) MRI Score for Hemophilic Arthropathy
Assessment of knee hemophilic arthropathy severity using the International Prophylaxis Study Group (IPSG) MRI scoring system. This scoring system evaluates early and advanced joint changes such as synovial hypertrophy, hemosiderin deposition, and cartilage/bone damage.
Time frame
After completion of MRI scanning session (within the same study visit). Overall Study Duration: 2 years (for recruitment, imaging, and data analysis).Secondary outcomes
1
Pettersson X-ray Score for Hemophilic Arthropathy
Assessment of knee hemophilic arthropathy severity using the Pettersson X-ray scoring system. This system evaluates joint space narrowing, osteoporosis, subchondral cysts, erosions, and bone deformities to quantify the degree of arthropathy.
Time frame
After completion of X-ray scanning session (within the same study visit). Overall Study Duration: 2 years (including recruitment, imaging, and data analysis).2
Agreement Between MRI and X-ray Scoring Systems in Hemophilic Arthropathy
To evaluate the agreement between the International Prophylaxis Study Group (IPSG) MRI score and the Pettersson X-ray score in assessing the severity of knee hemophilic arthropathy. This outcome will determine the level of concordance between the two imaging modalities in detecting joint changes.
Time frame
After completion of MRI and X-ray scanning sessions (within the same study visit). Overall study duration: 2 years (including recruitment, imaging, and data analysis).Locations
Sponsors and contacts
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Source ClinicalTrials.gov
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