MRI Volumetry and Diffusion Tensor Imaging in Temporal Lobe Epilepsy
ConditionTemporal Lobe Epilepsy (TLE)
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age12-50
SponsorAssiut University
About this trial
This works aims at evaluating the diagnostic performance of combined MRI Volumetry, Diffusion tensor imaging and Conventional MRI in lateralizing the epileptogenic focus in patients with temporal lobe epilepsy and correlate these findings with clinical outcome.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Patients with different age groups having temporal lobe epilepsy diagnosed by EEG with no detected structural brain lesion by conventional MRI other than mesial temporal sclerosis.
Disqualifiers
Contraindications for MRI as claustrophobia, cardiac pacemaker and non-compatible metallic devices.
Patients with suboptimal images or techniques.
Post-operative and post-head traumatic cases.
Trial population
Patients with idiopathic temporal lobe epilepsy and healthy volunteers
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
MRI
DeviceMRI volumetry and Diffusion Tensor Imaging
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Hippocampal mean diffusivity (MD) values measured by diffusion tensor imaging (DTI) in patients with temporal lobe epilepsy and non-epileptic control subjects.
Bilateral hippocampal MD values will be measured in square millimeters per second (mm²/s) by diffusion tensor imaging (DTI). MD value of the epileptogenic hippocampus will be compared with the contralateral side and with hippocampal MD values of age- and sex-matched control subjects.
Time frame
BaselineLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: