About this trial
This large real-world international prospective registry will provide a unique opportunity to comprehensively understand the contemporary management, clinical course and short as well as long-term outcomes of all Cardiogenic Shock (CS) patients cared for at four high volume dedicated shock care centers. As the first true North American multicenter CS collaborative with a uniform dedicated and comprehensive case report form, the high patient volumes and wide spectrum of clinical acuity seen at these institutions will provide valuable insight into the factors associated with adverse outcomes; and will serve as a blueprint for future clinical trial designs that may better inform clinical practice.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Primary diagnosis of cardiogenic shock at time of index evaluation; including acute myocardial infarction- and acute decompensated heart failure-cardiogenic shock phenotypes
Patients with cardiac arrest complicating cardiogenic shock and those with massive pulmonary embolism with right ventricular cardiogenic shock will also be eligible for the registry
Disqualifiers
Patients with shock not due to primary cardiac etiology will be excluded. These include septic, hemorrhagic, and anaphylactic shock.
Trial population
Patients presenting with cardiogenic shock at one of four high-volume North American quaternary care centers (Inova Heart and Vascular Institute, Sentara Norfolk General Hospital, University of Toronto and University of Utah)
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Survival
Percentage of participants alive at analysis time points
Secondary outcomes
Vascular Complications
Percentage of participants experiencing stroke or need for renal replacement therapy
Major Adverse Cardiovascular and Cerebrovascular Events
Percentage of participants experiencing myocardial infarction, stroke or heart failure re-hospitalization
Neurologic Status
Average participant neurologic status, as determined by the Cerebral Performance Category instrument
Health-related Quality of Life
Average participant health-related quality of life score, using the Rand 36-Item Short Form Survey
Sponsors and contacts
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STAVROS G DRAKOS
Lead sponsor
University of Utah
Sponsor institution