PROSAH-MPC, a collaborative research project among neurosurgical centers in China, focuses on aneurysmal subarachnoid hemorrhage (aSAH). Its aim is to identify prognostic factors and develop robust prediction models for complications, disability, and mortality in aSAH patients. By leveraging a large, multi-center, prospective cohort design, PROSAH-MPC aims to overcome limitations of past studies and provide a more comprehensive understanding of the disease.
Subarachnoid hemorrhage confirmed by computed tomography (CT);
Cerebral angiography (CTA) and digital subtraction angiography (DSA) examination confirming intracranial aneurysm rupture as the cause of the subarachnoid hemorrhage;
Blood routine, biochemical function, blood coagulation function, and craniocerebral CT performed within 24 hours of symptom onset;
Underwent aneurysm clipping by surgery or endovascular embolization within 72 hours after-onset.
Aneurysm rupture bleeding time exceeding 24 hours before hospital admission;
Incomplete image data or blood test information;
Long-term use of anticoagulant medications such as aspirin or warfarin;
Admitted to hospital with active infectious diseases;
Patients with Aneurysmal Subarachnoid Hemorrhage (aSAH)
Cohort
Prospective
Machine Leaning Models
Diagnostic testArea Under the Curve (ROC): Measures the overall performance of the model across all classification thresholds. A higher AUC value indicates better performance. Accuracy: The proportion of correctly predicted outcomes (both positive and negative) out of all predictions made. Precision (Positive Predictive Value, PPV): The proportion of correctly predicted positive outcomes out of all predicted positive outcomes. Sensitivity (True Positive Rate, TPR): The proportion of actual positive outcomes that are correctly identified by the model. Specificity (True Negative Rate, TNR): The proportion of actual negative outcomes that are correctly identified by the model.
modified Rankin Scale (mRS) for evaluating the prognosis
A score of 3 or greater on the mRS indicates a poor prognosis, with significant disability or dependence on others for daily activities. A score less than 3 indicates a good prognosis, with the patient being able to live independently with minimal or no disability.
Delayed cerebral ischemia (DCI)
DCI is a common complication after aSAH and refers to a decline in neurological status or the presence of new infarctions on imaging, typically occurring days to weeks after the initial hemorrhage.
Rebleeding
This outcome measures the occurrence of recurrent intracranial hemorrhage from the same or another aneurysm within the study period.
Intracranial Aneurysm Re-Rupture
This refers to the re-rupture of the aneurysm that caused the initial aSAH or the rupture of a different aneurysm.
Hydrocephalus
Hydrocephalus is the abnormal accumulation of cerebrospinal fluid in the brain's ventricles, leading to their dilation.
Clearing Rate of Subarachnoid Hemorrhage
This outcome measures the reduction in the volume of subarachnoid hemorrhage over time, quantified using BrainHemoAI software by comparing admission CT scans to subsequent scans (e.g., at discharge or follow-up).
Click on the lead sponsor to view all of their trials.
Second Affiliated Hospital of Nanchang University
Lead sponsor
Panzhihua Central Hospital
Collaborator
Zhujiang Hospital
Collaborator
Southwest Hospital, China
Collaborator
Renmin Hospital of Wuhan University
Collaborator
