Health TrialsbyHealthPanel

Multi-model Image of Doxycycline in TAO

ConditionThyroid Associated Ophthalmopathy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorSun Yat-sen University

About this trial

This study aims to evaluate the efficacy of doxycycline treating Thyroid Associated Ophthalmopathy by multi-modal image.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Informed consent

Age 18-70 years old

Diagnosed with TAO

Disqualifiers

Sight-threatening TAO with dysthyroid optic neuropathy

Allergy of tetracycline

Have contraindications of MRI(metal pacemaker, fake teeth, foreign body and other materials which will disturb the examination)

Trial design

Design model

Single group

Treatments tested in this trial

  • Doxycycline Hyclate

    Drug

    patients administrated with doxycycline tablets 100mg orally per day

Treatment groups

20 Participants
are divided into 1 treatment group
Group A: doxycyclineExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

change of extraocular muscle volume and orbital fat volume by MRI

3D MRI image will be established and the volume of extraocular muscle and orbital fat will be calculated by the same advanced programmer who is blinded of the pre- or post- treatment images order. A higher score means a better outcome.

Time frame
at month 6

Secondary outcomes

1

change of exophthalmos

exophthalmos will be measured by the same investigator using the same Hertel instrument. A higher change of exphthalmos means a better outcome.

Time frame
at month 6
2

change of Quality of Life

The score of quality of life will be assessed by the same investigator using GO-QoL. The better change of quality of life means a better outcome.

Time frame
at month 6
3

change of eyelid aperture, lid retraction and lid lag

the values will be measured by the same investigator using the same millimeter ruler and the higher values change, the better the outcome is.

Time frame
at month 6

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sun Yat-sen University

Lead sponsor

Source ClinicalTrials.gov
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