Multi-Omic SignAtures of Inflammatory Cutaneous Diseases
ConditionInflammatory Skin Conditions
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorGuy's and St Thomas' NHS Foundation Trust
About this trial
The goal of this observational study is to identify the immune profile underlying various inflammatory skin diseases, through multi-omic procedures.
The main questions it aims to answer are:
1. What are the molecular and immune signatures of individuals with inflammatory skin disease? 2. Can these signatures reveal potential therapeutic targets for individuals with inflammatory skin disease? 3. How do patients' multi-omic signatures change before and after receiving systemic therapy? 4. Can the samples and data collected through this study provide a valuable bioresource for future skin disease research?
Eligibility criteria
Qualifiers
Able to provide written informed consent prior to performing any protocol-related procedures, including screening.
Adults (≥18 years) with confirmed diagnosis of inflammatory skin disease (defined as any skin disease with an inflammatory component, including but not limited to, genetic skin disease, such as EB), OR
Adults age (≥18 years) without skin or systemic disease.
Disqualifiers
Inability to give written informed consent.
Participants who have received topical corticosteroids to sites of biopsies (inflamed area of skin) for at least 2 weeks prior to tissue sampling.
Inability to participate in study-specific procedures.
Participants who are pregnant (confirmed on a positive urine pregnancy test) or breastfeeding
Trial design
Treatments tested in this trial
- Not listed
Trial groups
400 Participants
are grouped into 2 trial groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov