A vision-language model using preoperative MRI and clinical variables has been developed to simultaneously predict three key molecular markers in midline gliomas: H3K27M, IDH, and 1p/19q. This prospective multicenter study will validate the model's accuracy in preoperative molecular subtyping and its value in prognostic assessment and clinical decision-making across multiple neurosurgical centers.
Patients with diffuse gliomas were pathologically and molecularly diagnosed.
The clinical case data of all patients were complete.
Patients underwent preoperative MRI examination.
The tumor is not located in the intracranial midline.
Cases in which MRI were incomplete or with significant noise and artifacts.
Patients with diffuse gliomas located in the intracranial midline.
Case-only
Prospective
Not listed
Diagnostic accuracy for midline glioma molecular subtypes
Model predictions compared with postoperative histopathology and molecular testing (gold standard). Performance metrics include AUC, F1 score, sensitivity, specificity, and accuracy.
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